Acquisition of aneuploidy in evolved Candida albicans strains increases their fitness in the murine gastrointestinal tract

• Main Author: Tan, Alvin Yong Quan
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Microbiology; DRNTU::Science::Biological sciences::Genetics; DRNTU::Science::Biological sciences::Evolution
• Online Access: http://hdl.handle.net/10356/59760
• Institution: Nanyang Technological University

Candida albicans is an important human fungal pathogen that behaves as a benign commensal in most healthy individuals, but becomes pathogenic when the host is under immunocompromised conditions. The high plasticity of the C. albicans genome has been associated to its ability to rapidly adapt to hars...