Multi-resolution functional summarization and alignment of biological network models

• Main Author: Seah, Boon Siew
• Other Authors: C. Forbes Dewey, Jr.
• Format: Theses and Dissertations
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/60641
• Institution: Nanyang Technological University

The desire to study biology from a systems perspective has led to an emergence of new science - biological networks analysis. Biological network models biological entities (e.g., proteins and genes) and their relationships (e.g., physical and genetic interactions) to characterize their cooperative activity within a system. With the rapid growth of network data, the information overload problem arises and human interpretation of such data becomes impossible. Hence, there is urgent need to construct methods for large-scale functional visualization of biological networks to understand the mechanics of biological systems.