Multifunctional chitosan microneedle patches for sustained transdermal drug delivery
The growing popularity of transdermal drug delivery as one of the routes of drug administration has been observed in the recent years. It has been used to deliver low molecular weight drugs into patient, prevent drug degradation and also offers controlled release of the drug. The major problem encou...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2014
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| Online Access: | http://hdl.handle.net/10356/60807 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The growing popularity of transdermal drug delivery as one of the routes of drug administration has been observed in the recent years. It has been used to deliver low molecular weight drugs into patient, prevent drug degradation and also offers controlled release of the drug. The major problem encountered for drug delivery is the stratum corneum which is the outer layer of skin as it does not transport hydrophilic and high molecular weight drug using passive patches due to its low diffusion coefficient.
Microneedle has been used in many areas in studying of transdermal drug delivery, blood extraction, and skin care fields. With the development of microneedles for transdermal delivery, the administration is targeted at the stratum corneum of the human skin and the microneedles do not cause as much pain as hypodermic needle for patients and it allows a faster, efficient, sustained transdermal drug delivery. Hence the microneedles are safe, painless as they do not have a chance to come in contact with the nerves to cause a pain sensation.
In this project, these microneedles were fabricated by using chitosan powder as chitosan is biocompatible, degradable, and nontoxic to human body. The goal of this project is to target for a self-administered treatment of keloids by transdermal drug delivery through chitosan microneedle. Keloid is formed when there is an overgrowth of scar tissues at the site of injury after the injury has healed. Hence, through this non-invasive drug delivery system to treat keloids is to be explored. |
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