Microfluidics based cell-cell interaction model

Micro fluidics is a term which defines the technology that is a combination of fluid mechanics, biology and chemistry .This technology facilitates the flow of micro and nano scale volumes through the miniaturized channels for many biological applications. The purpose of this study is to tar...

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Main Author: Bak Thavatchalam, Subhashree
Other Authors: School of Chemical and Biomedical Engineering
Format: Theses and Dissertations
Language:English
Published: 2014
Subjects:
Online Access:http://hdl.handle.net/10356/61107
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-611072023-03-03T16:07:11Z Microfluidics based cell-cell interaction model Bak Thavatchalam, Subhashree School of Chemical and Biomedical Engineering Kang, Yue Jun DRNTU::Engineering Micro fluidics is a term which defines the technology that is a combination of fluid mechanics, biology and chemistry .This technology facilitates the flow of micro and nano scale volumes through the miniaturized channels for many biological applications. The purpose of this study is to target at one of the upcoming research field (i.e.) the in vitro diagnostics for co-culture systems. The combination of the micro fluid platform along with cell culture to study the cell-cell interaction facilitates the complex interactions between the cancer cells and human stromal cells that occur during metastasis in vitro is an example of cell-cell interaction which is quite difficult to understand, so a micro fluidic model that provides better understanding of the invasion of the cancer cells is needed. In this study such a microfuidic chip has been developed whereby the bone marrow stromal cells have been cultured within the chip in a 3D microenvironment. This chip can be used to study various phenomena like cell-cell interactions, cell-matrix interactions, cell migration, etc. The results obtained from this study forms the milestone for the future potential bio mimetic micro systems as a replacement of lab animals in in vitro diagnostics. ​Master of Science (Biomedical Engineering) 2014-06-04T09:16:51Z 2014-06-04T09:16:51Z 2014 2014 Thesis http://hdl.handle.net/10356/61107 en 57 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering
spellingShingle DRNTU::Engineering
Bak Thavatchalam, Subhashree
Microfluidics based cell-cell interaction model
description Micro fluidics is a term which defines the technology that is a combination of fluid mechanics, biology and chemistry .This technology facilitates the flow of micro and nano scale volumes through the miniaturized channels for many biological applications. The purpose of this study is to target at one of the upcoming research field (i.e.) the in vitro diagnostics for co-culture systems. The combination of the micro fluid platform along with cell culture to study the cell-cell interaction facilitates the complex interactions between the cancer cells and human stromal cells that occur during metastasis in vitro is an example of cell-cell interaction which is quite difficult to understand, so a micro fluidic model that provides better understanding of the invasion of the cancer cells is needed. In this study such a microfuidic chip has been developed whereby the bone marrow stromal cells have been cultured within the chip in a 3D microenvironment. This chip can be used to study various phenomena like cell-cell interactions, cell-matrix interactions, cell migration, etc. The results obtained from this study forms the milestone for the future potential bio mimetic micro systems as a replacement of lab animals in in vitro diagnostics.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Bak Thavatchalam, Subhashree
format Theses and Dissertations
author Bak Thavatchalam, Subhashree
author_sort Bak Thavatchalam, Subhashree
title Microfluidics based cell-cell interaction model
title_short Microfluidics based cell-cell interaction model
title_full Microfluidics based cell-cell interaction model
title_fullStr Microfluidics based cell-cell interaction model
title_full_unstemmed Microfluidics based cell-cell interaction model
title_sort microfluidics based cell-cell interaction model
publishDate 2014
url http://hdl.handle.net/10356/61107
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