Texture analysis of muscle in lower extremities MRI for detection of sarcopenia
Sarcopenia is an age dependent syndrome that is characterized by the progressive loss of skeletal muscle mass, function and performance in conjunction with increased fat mass, increasing the risk of adverse outcomes such as physical disability, poor quality of life and higher mortality rate...
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Format: | Theses and Dissertations |
Language: | English |
Published: |
2014
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Online Access: | http://hdl.handle.net/10356/61113 |
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Institution: | Nanyang Technological University |
Language: | English |
Summary: | Sarcopenia is an age dependent syndrome that is characterized by the progressive loss of
skeletal muscle mass, function and performance in conjunction with increased fat mass,
increasing the risk of adverse outcomes such as physical disability, poor quality of life
and higher mortality rate. Some of the causes of sarcopenia include lack of physical
activity, neuromuscular loss, poor nutrition, hormonal changes, inflammation, chronic
diseases and high muscular fat content. Previously it was presumed that age related
weight loss, together with muscle mass loss, was largely responsible for muscle frailty in
the elderly resulting in sarcopenia. However, recent studies have shown that changes in
muscle composition are also critical, as higher amounts of fat infiltration in muscle
lowers muscle quality and work performance. In this study we aim to utilize textural
parameters for analysis of MRI images of the lower extremities (mid-thigh to calf
region), to see if they can be used as indicators to differentiate between healthy and frail
subjects as well as determining their correlation to fat infiltrations in muscle. Results
showed that entropy, grey level non-uniformity and kurtosis may be used as an indicator
to distinguish between healthy and frail subject groups and they exhibit a clear
relationship with fat infiltrates density in muscle. These results could be useful for the
early detection of sarcopenia so that adverse outcomes can be prevented and controlled. |
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