Apelin suprresses ROS production in macrophages

Oxidative stress is a condition when antioxidants defence mechanisms are overwhelmed by reactive oxygen species (ROS). Oxidative stress due to overproduction of ROS is a key contributor to pathogenicity of obesity and its related metabolic disorders. Adipose tissue is recognized as a complex organ c...

Full description

Saved in:
Bibliographic Details
Main Author: Myat, Thiri Maw
Other Authors: Chen Peng
Format: Theses and Dissertations
Language:English
Published: 2014
Subjects:
Online Access:http://hdl.handle.net/10356/61117
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-61117
record_format dspace
spelling sg-ntu-dr.10356-611172023-03-03T16:07:46Z Apelin suprresses ROS production in macrophages Myat, Thiri Maw Chen Peng School of Chemical and Biomedical Engineering DRNTU::Engineering Oxidative stress is a condition when antioxidants defence mechanisms are overwhelmed by reactive oxygen species (ROS). Oxidative stress due to overproduction of ROS is a key contributor to pathogenicity of obesity and its related metabolic disorders. Adipose tissue is recognized as a complex organ consists of various cell types including adipocytes and macrophages. Macrophages in adipose tissue are major source of ROS found in obesity. Apelin is one of adipokines secreted by adipose tissue and known for anti-diabetic and anti-obesity properties. Plasma apelin has been identified as circulation hormones and both apelin level and oxidative stress are increased in obesity. However, role of apelin regulation on ROS production in macrophages remain unknown. In present study, we provide the evidence that apelin supresses ROS production in macrophages. We also observed that apelin is able to abolish the TNFα -induced dysregulation of anti- and pro-oxidant enzymes expression in macrophages. In addition, we further observed that apelin promotes anti-oxidant enzymes through PI3K /Akt pathway, and suppresses the expression of pro-oxidant enzymes via MAPK/ERK pathway. This study reveals that anti-oxidant properties of apelin in macrophages, and suggests its potential application as a novel therapeutic target for metabolic diseases. ​Master of Science (Biomedical Engineering) 2014-06-05T02:54:27Z 2014-06-05T02:54:27Z 2014 2014 Thesis http://hdl.handle.net/10356/61117 en 85 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering
spellingShingle DRNTU::Engineering
Myat, Thiri Maw
Apelin suprresses ROS production in macrophages
description Oxidative stress is a condition when antioxidants defence mechanisms are overwhelmed by reactive oxygen species (ROS). Oxidative stress due to overproduction of ROS is a key contributor to pathogenicity of obesity and its related metabolic disorders. Adipose tissue is recognized as a complex organ consists of various cell types including adipocytes and macrophages. Macrophages in adipose tissue are major source of ROS found in obesity. Apelin is one of adipokines secreted by adipose tissue and known for anti-diabetic and anti-obesity properties. Plasma apelin has been identified as circulation hormones and both apelin level and oxidative stress are increased in obesity. However, role of apelin regulation on ROS production in macrophages remain unknown. In present study, we provide the evidence that apelin supresses ROS production in macrophages. We also observed that apelin is able to abolish the TNFα -induced dysregulation of anti- and pro-oxidant enzymes expression in macrophages. In addition, we further observed that apelin promotes anti-oxidant enzymes through PI3K /Akt pathway, and suppresses the expression of pro-oxidant enzymes via MAPK/ERK pathway. This study reveals that anti-oxidant properties of apelin in macrophages, and suggests its potential application as a novel therapeutic target for metabolic diseases.
author2 Chen Peng
author_facet Chen Peng
Myat, Thiri Maw
format Theses and Dissertations
author Myat, Thiri Maw
author_sort Myat, Thiri Maw
title Apelin suprresses ROS production in macrophages
title_short Apelin suprresses ROS production in macrophages
title_full Apelin suprresses ROS production in macrophages
title_fullStr Apelin suprresses ROS production in macrophages
title_full_unstemmed Apelin suprresses ROS production in macrophages
title_sort apelin suprresses ros production in macrophages
publishDate 2014
url http://hdl.handle.net/10356/61117
_version_ 1759858093423853568