Microbial production of steroids-anticancer agents

Steroids are one of the most important compounds in the pharmaceutical industry. These biodynamic agents are the most widely marketed products in the industry. They are widely utilized for development of drugs due to their affinities to various nuclear receptors. Steroidal biochemistry and its role...

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Main Author: Preetha Nair
Other Authors: School of Chemical and Biomedical Engineering
Format: Theses and Dissertations
Language:English
Published: 2014
Subjects:
Online Access:http://hdl.handle.net/10356/61126
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-611262023-03-03T16:02:43Z Microbial production of steroids-anticancer agents Preetha Nair School of Chemical and Biomedical Engineering Song Hao DRNTU::Engineering Steroids are one of the most important compounds in the pharmaceutical industry. These biodynamic agents are the most widely marketed products in the industry. They are widely utilized for development of drugs due to their affinities to various nuclear receptors. Steroidal biochemistry and its role in physiology of humans along with the selectivity and stereo specificity in their reactions, gives rise to the production of functionalized compounds with therapeutic use and high commercial value. These characteristics of steroids with certain conditions required for biological transformation led to processes with biological steroidal derivatives, more environmentally friendly than their chemical counterparts. The modifications in steroids have become a prime focus in the recent researches. Some of the successful steroidal pharmacophores are exemestane, SR16157, fulvestrant and 2-methoxyestradiol. Several steroidal compounds against cancerous cells such as cytotoxic and cytostatic molecules of both natural and synthetic origin have been shown. In this review an overview is given on the developments and advancements on steroidal production by use of microorganisms in the recent years is presented. ​Master of Science (Biomedical Engineering) 2014-06-05T05:35:04Z 2014-06-05T05:35:04Z 2014 2014 Thesis http://hdl.handle.net/10356/61126 en 51 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering
spellingShingle DRNTU::Engineering
Preetha Nair
Microbial production of steroids-anticancer agents
description Steroids are one of the most important compounds in the pharmaceutical industry. These biodynamic agents are the most widely marketed products in the industry. They are widely utilized for development of drugs due to their affinities to various nuclear receptors. Steroidal biochemistry and its role in physiology of humans along with the selectivity and stereo specificity in their reactions, gives rise to the production of functionalized compounds with therapeutic use and high commercial value. These characteristics of steroids with certain conditions required for biological transformation led to processes with biological steroidal derivatives, more environmentally friendly than their chemical counterparts. The modifications in steroids have become a prime focus in the recent researches. Some of the successful steroidal pharmacophores are exemestane, SR16157, fulvestrant and 2-methoxyestradiol. Several steroidal compounds against cancerous cells such as cytotoxic and cytostatic molecules of both natural and synthetic origin have been shown. In this review an overview is given on the developments and advancements on steroidal production by use of microorganisms in the recent years is presented.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Preetha Nair
format Theses and Dissertations
author Preetha Nair
author_sort Preetha Nair
title Microbial production of steroids-anticancer agents
title_short Microbial production of steroids-anticancer agents
title_full Microbial production of steroids-anticancer agents
title_fullStr Microbial production of steroids-anticancer agents
title_full_unstemmed Microbial production of steroids-anticancer agents
title_sort microbial production of steroids-anticancer agents
publishDate 2014
url http://hdl.handle.net/10356/61126
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