Palladium-catalyzed stereoselective glycosylation with glycal donors : novel strategies for the construction of diverse glycosidic linkages
Carbohydrates play essential roles in many complex biological processes and are readily available from a wide range of natural sources. The development of glycobiology science has stimulated the growth in demand for oligosaccharides and glycoconjugates in the last few decades. As such, the construct...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2015
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| Online Access: | https://hdl.handle.net/10356/62107 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Carbohydrates play essential roles in many complex biological processes and are readily available from a wide range of natural sources. The development of glycobiology science has stimulated the growth in demand for oligosaccharides and glycoconjugates in the last few decades. As such, the construction of glycosidic bonds has increased in significance. In this section, a brief introduction to glycosylation and some main factors that affect the stereoselectivity such as anomeric effect, solvent effect and neighbouring group participation are discussed. Besides that, selected well-designed strategies to achieve stereocontrolled glycosylation are also presented. Thereafter, the recent development of transition metal catalyzed glycosylation with glycosyl-type donor is summarized to provide a basic foundation for the extension of our work. |
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