Molecular and genetic dissection of dilated cardiomyopathy

• Main Author: Hafizah Khalidh
• Other Authors: Li Guang
• Format: Final Year Project
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/62952
• Institution: Nanyang Technological University

Dilated Cardiomyopathy (DCM), caused by mutations in more than 30 genes, is a life– threatening disease with an estimated prevalence of 1:250. TTN-truncating variants (TTNtv) by nonsense mutations are the most common (~27%) genetic cause of DCM. Around one in 50 people have TTNtv. However, only far...