Regulation of smooth muscle cells using UV embossed microchannelled polymeric films

Regulation of smooth muscle cells using UV embossed microchannelled polymeric films

The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic S...

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Main Author: Shen, Jinye
Other Authors: Chan Bee Eng, Mary
Format: Theses and Dissertations
Published: 2008
Subjects:
DRNTU::Engineering::Bioengineering
Online Access:https://hdl.handle.net/10356/6361
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-63612023-03-11T17:46:04Z Regulation of smooth muscle cells using UV embossed microchannelled polymeric films Shen, Jinye Chan Bee Eng, Mary School of Mechanical and Aerospace Engineering DRNTU::Engineering::Bioengineering The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic SMC is desired for cell proliferation needed for vessel remodeling but the contractile phenotype is necessary for sufficient vasoactivity and inhibition of neoinitima formation. The switch of SMC phenotype from synthetic to contractile at the appropriate cell development stage has been hypothesized to be necessary for producing a functional vascular tunica media. DOCTOR OF PHILOSOPHY (MAE) 2008-09-17T11:12:53Z 2008-09-17T11:12:53Z 2008 2008 Thesis Shen, J. (2008). Regulation of smooth muscle cells using UV embossed microchannelled polymeric films. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/6361 10.32657/10356/6361 Nanyang Technological University application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Shen, Jinye
Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
description The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic SMC is desired for cell proliferation needed for vessel remodeling but the contractile phenotype is necessary for sufficient vasoactivity and inhibition of neoinitima formation. The switch of SMC phenotype from synthetic to contractile at the appropriate cell development stage has been hypothesized to be necessary for producing a functional vascular tunica media.
author2 Chan Bee Eng, Mary
author_facet Chan Bee Eng, Mary
Shen, Jinye
format Theses and Dissertations
author Shen, Jinye
author_sort Shen, Jinye
title Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
title_short Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
title_full Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
title_fullStr Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
title_full_unstemmed Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
title_sort regulation of smooth muscle cells using uv embossed microchannelled polymeric films
publishDate 2008
url https://hdl.handle.net/10356/6361
_version_ 1761781668182491136

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