Targeted drug delivery in atherosclerosis

Coronary artery disease (CAD) induced by atherosclerosis is the main cause of mortality and morbidity in the world. The fundamental pathogenesis associates with an imbalanced lipid metabolism as well as a non-adaptive immune response triggering a chronic inflammation of the arterial wall. Dexamethas...

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Main Author: Cui, Ming Yue
Other Authors: Chan Juliana Maria Shu Ping
Format: Theses and Dissertations
Language:English
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10356/64404
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-644042023-03-03T15:58:52Z Targeted drug delivery in atherosclerosis Cui, Ming Yue Chan Juliana Maria Shu Ping School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering Coronary artery disease (CAD) induced by atherosclerosis is the main cause of mortality and morbidity in the world. The fundamental pathogenesis associates with an imbalanced lipid metabolism as well as a non-adaptive immune response triggering a chronic inflammation of the arterial wall. Dexamethasone (Dex) is a popular anti-inflammatory worldwide, if we can specifically deliver it to the inflammatory region, the symptoms should be relieved and have few side effects. Therefore, the objective of this project is to put the anti-inflammatory drug (Dex) into carrier (Poly D, L-lactic-co-glycolic acid polymer) to specially target foam cells, then prevent the subsequent diseases or complications induced by atherosclerosis, therefore, the drug dose and side effects could be lowed. During this process, characterize the particles via Dynamic Light Scattering (DLS), High Performance Liquid Chromatography (HPLC) to find the appropriate weight ratio of polymer and drug. ​Master of Science (Biomedical Engineering) 2015-05-26T06:58:07Z 2015-05-26T06:58:07Z 2015 2015 Thesis http://hdl.handle.net/10356/64404 en 48 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Cui, Ming Yue
Targeted drug delivery in atherosclerosis
description Coronary artery disease (CAD) induced by atherosclerosis is the main cause of mortality and morbidity in the world. The fundamental pathogenesis associates with an imbalanced lipid metabolism as well as a non-adaptive immune response triggering a chronic inflammation of the arterial wall. Dexamethasone (Dex) is a popular anti-inflammatory worldwide, if we can specifically deliver it to the inflammatory region, the symptoms should be relieved and have few side effects. Therefore, the objective of this project is to put the anti-inflammatory drug (Dex) into carrier (Poly D, L-lactic-co-glycolic acid polymer) to specially target foam cells, then prevent the subsequent diseases or complications induced by atherosclerosis, therefore, the drug dose and side effects could be lowed. During this process, characterize the particles via Dynamic Light Scattering (DLS), High Performance Liquid Chromatography (HPLC) to find the appropriate weight ratio of polymer and drug.
author2 Chan Juliana Maria Shu Ping
author_facet Chan Juliana Maria Shu Ping
Cui, Ming Yue
format Theses and Dissertations
author Cui, Ming Yue
author_sort Cui, Ming Yue
title Targeted drug delivery in atherosclerosis
title_short Targeted drug delivery in atherosclerosis
title_full Targeted drug delivery in atherosclerosis
title_fullStr Targeted drug delivery in atherosclerosis
title_full_unstemmed Targeted drug delivery in atherosclerosis
title_sort targeted drug delivery in atherosclerosis
publishDate 2015
url http://hdl.handle.net/10356/64404
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