Analytical characteristics of developing a multiplexed bioassay using circulating cell-free tumor DNA to simultaneously detect primary and secondary (acquired) mutations in patients with advanced gastrointestinal stromal tumors

• Main Author: Lim, Rebecca Rui Jia
• Other Authors: Tan, Iain Bee Huat
• Format: Final Year Project
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/64724
• Institution: Nanyang Technological University

Gastrointestinal stromal tumors (GISTs) are mesenchymal malignancies characterized by a set of primary mutations mainly in KIT and PDGFRα. Secondary mutations conferring resistance to targeted therapeutic drugs also tend to arise along the course of clinical treatment. The presence of circulating tu...