Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats

The adaptive nature of active coping has been known to enable the promotion of stress resilience and the reduction of vulnerability to neuropsychiatric disorders. But because of developmental plasticity, this ability to adapt and handle stress is largely shaped by the early-life environment. Thus, f...

Full description

Saved in:
Bibliographic Details
Main Author: Hong, Huiying
Other Authors: Rupshi Mitra
Format: Final Year Project
Language:English
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10356/64728
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-64728
record_format dspace
spelling sg-ntu-dr.10356-647282023-02-28T18:01:15Z Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats Hong, Huiying Rupshi Mitra School of Biological Sciences DRNTU::Science::Biological sciences::Zoology::Animal behavior The adaptive nature of active coping has been known to enable the promotion of stress resilience and the reduction of vulnerability to neuropsychiatric disorders. But because of developmental plasticity, this ability to adapt and handle stress is largely shaped by the early-life environment. Thus, factors like the type of environmental stressors experienced and the timing of stress exposure in relation to the critical stages of development play a vital role in determining the susceptibility one has to the neuropsychiatric disorders and it becomes crucial to find out how they impact future behaviour so that we can better understand active coping abilities and use the knowledge to find ways to tackle the mental health problem. Therefore, a comparison involving the Light-Dark Box (LDB), Elevated-Plus Maze (EPM), and Aggression Test (AGT), was carried out to see how four different early-life environments, namely Maternal Separation (MS), Limited Nesting (LN), Enriched Environment (EE) and Animal Facility Rearing (AFR), affected aggression and anxiety-related behaviours in adolescent and adult rat models. Each behavioural parameter was quantified and analysed using One-way ANOVA and Fisher’s LSD test and results found that only MS displayed a significant ability to reduce anxiety and increase risk-assessment behaviour in adulthood, which is contradictory to prior literature. Hence, checks were done and the nearby construction site was found to have influenced the animals and compromised the accuracy of the results. Thus, a re-run of the study has to be done in future for verification of the results obtained. Bachelor of Science in Biological Sciences 2015-05-29T08:11:34Z 2015-05-29T08:11:34Z 2015 2015 Final Year Project (FYP) http://hdl.handle.net/10356/64728 en Nanyang Technological University 32 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Zoology::Animal behavior
spellingShingle DRNTU::Science::Biological sciences::Zoology::Animal behavior
Hong, Huiying
Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats
description The adaptive nature of active coping has been known to enable the promotion of stress resilience and the reduction of vulnerability to neuropsychiatric disorders. But because of developmental plasticity, this ability to adapt and handle stress is largely shaped by the early-life environment. Thus, factors like the type of environmental stressors experienced and the timing of stress exposure in relation to the critical stages of development play a vital role in determining the susceptibility one has to the neuropsychiatric disorders and it becomes crucial to find out how they impact future behaviour so that we can better understand active coping abilities and use the knowledge to find ways to tackle the mental health problem. Therefore, a comparison involving the Light-Dark Box (LDB), Elevated-Plus Maze (EPM), and Aggression Test (AGT), was carried out to see how four different early-life environments, namely Maternal Separation (MS), Limited Nesting (LN), Enriched Environment (EE) and Animal Facility Rearing (AFR), affected aggression and anxiety-related behaviours in adolescent and adult rat models. Each behavioural parameter was quantified and analysed using One-way ANOVA and Fisher’s LSD test and results found that only MS displayed a significant ability to reduce anxiety and increase risk-assessment behaviour in adulthood, which is contradictory to prior literature. Hence, checks were done and the nearby construction site was found to have influenced the animals and compromised the accuracy of the results. Thus, a re-run of the study has to be done in future for verification of the results obtained.
author2 Rupshi Mitra
author_facet Rupshi Mitra
Hong, Huiying
format Final Year Project
author Hong, Huiying
author_sort Hong, Huiying
title Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats
title_short Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats
title_full Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats
title_fullStr Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats
title_full_unstemmed Effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats
title_sort effects of early-life stress and early-life enrichment on adolescent and adult behaviour in rats
publishDate 2015
url http://hdl.handle.net/10356/64728
_version_ 1759855914908647424