Bio-mimicry of trace element in bone tissue engineering

In bone tissue engineering, the combination of bio-scaffolds and cells facilitates the regeneration of bone tissues. It provides a sustainable alternative approach to fix the critical sized defects in bone fractures, an increasing phenomenon especially with the rising occurrence of osteoporosis. Sca...

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Main Author: Chee, Cui Xia
Other Authors: Teoh Swee Hin
Format: Final Year Project
Language:English
Published: 2015
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Online Access:http://hdl.handle.net/10356/64981
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-649812023-03-03T15:36:10Z Bio-mimicry of trace element in bone tissue engineering Chee, Cui Xia Teoh Swee Hin School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering In bone tissue engineering, the combination of bio-scaffolds and cells facilitates the regeneration of bone tissues. It provides a sustainable alternative approach to fix the critical sized defects in bone fractures, an increasing phenomenon especially with the rising occurrence of osteoporosis. Scaffolds give a structural support and the appropriate guidance for the integration and growth of bone cells. This project aims to incorporate magnesium, an important trace element that plays a vital role in bone mineralization, with PCL and β-TCP, which has been established to promote osteogenic activities, to create filaments for scaffolds that mimic the human bones as closely as possible. Various compositions of PCL-TCP-Mg filaments, with 1, 10, 20, 40 wt% of β-TCP and 1 wt% of MgSO4 dopant are fabricated. Mechanical tests, degradation and biological experiments were carried out to evaluate their suitability as human bone scaffolds. The results indicated that the inclusion of Mg2+ and increasing β-TCP and Mg2+ reflected higher bone mineralization without any threats of cytotoxicity. In addition, trends in mechanical test and degradation profile showed positive impressions of increasing β-TCP and Mg2+ from 1 wt% to 20 wt% in its application of bone scaffolds. Based on the results established in this project, 80/20/1 PCL-TCP-Mg filament showed the greatest potential to be fabricated into scaffolds. However, it is important to note that mechanical and physical properties of scaffolds from these filaments could differ from the results obtained in this study due to other physical factors. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2015-06-10T03:06:08Z 2015-06-10T03:06:08Z 2015 2015 Final Year Project (FYP) http://hdl.handle.net/10356/64981 en Nanyang Technological University 60 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Chee, Cui Xia
Bio-mimicry of trace element in bone tissue engineering
description In bone tissue engineering, the combination of bio-scaffolds and cells facilitates the regeneration of bone tissues. It provides a sustainable alternative approach to fix the critical sized defects in bone fractures, an increasing phenomenon especially with the rising occurrence of osteoporosis. Scaffolds give a structural support and the appropriate guidance for the integration and growth of bone cells. This project aims to incorporate magnesium, an important trace element that plays a vital role in bone mineralization, with PCL and β-TCP, which has been established to promote osteogenic activities, to create filaments for scaffolds that mimic the human bones as closely as possible. Various compositions of PCL-TCP-Mg filaments, with 1, 10, 20, 40 wt% of β-TCP and 1 wt% of MgSO4 dopant are fabricated. Mechanical tests, degradation and biological experiments were carried out to evaluate their suitability as human bone scaffolds. The results indicated that the inclusion of Mg2+ and increasing β-TCP and Mg2+ reflected higher bone mineralization without any threats of cytotoxicity. In addition, trends in mechanical test and degradation profile showed positive impressions of increasing β-TCP and Mg2+ from 1 wt% to 20 wt% in its application of bone scaffolds. Based on the results established in this project, 80/20/1 PCL-TCP-Mg filament showed the greatest potential to be fabricated into scaffolds. However, it is important to note that mechanical and physical properties of scaffolds from these filaments could differ from the results obtained in this study due to other physical factors.
author2 Teoh Swee Hin
author_facet Teoh Swee Hin
Chee, Cui Xia
format Final Year Project
author Chee, Cui Xia
author_sort Chee, Cui Xia
title Bio-mimicry of trace element in bone tissue engineering
title_short Bio-mimicry of trace element in bone tissue engineering
title_full Bio-mimicry of trace element in bone tissue engineering
title_fullStr Bio-mimicry of trace element in bone tissue engineering
title_full_unstemmed Bio-mimicry of trace element in bone tissue engineering
title_sort bio-mimicry of trace element in bone tissue engineering
publishDate 2015
url http://hdl.handle.net/10356/64981
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