Use of a promiscuous biotin ligase to identify partners of the CRTC transcription factor

• Main Author: Nai, Rui Si
• Other Authors: Mark Stephen Featherstone
• Format: Final Year Project
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/65366
• Institution: Nanyang Technological University

CREB is an important transcription factor that is regulated in part by the CRTC family of cofactors. CRTCs work in tandem with CREB to mediate various metabolic processes, such as promoting gluconeogenesis in response to increased glucagon levels. CRTC1 in particular is highly expressed in the brai...