Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy
To complement the traditional silicon and glass-based microfluidic devices, polymer-based microdevices have attracted much more attention in recent years. Advantages of low cost, excellent mechanical property, low demands of facilities and reagents have further facilitated the development of polymer...
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sg-ntu-dr.10356-655712023-03-03T15:58:00Z Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy Xue, Peng Kang Yuejun School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering To complement the traditional silicon and glass-based microfluidic devices, polymer-based microdevices have attracted much more attention in recent years. Advantages of low cost, excellent mechanical property, low demands of facilities and reagents have further facilitated the development of polymer-based microdevices. Simultaneously, novel microfabrication techniques being developed enable the integration of microfluidic chips to achieve multiple analyses on the same chip, especially in the research fields of medical diagnostic assays and clinical therapy. Cancer is a critical disease with high lethal rate nowadays. Diagnostics and therapeutics of cancer are important subjects, and any relevant creativity may change human lives in future. Polymer-based microfluidic microdevices have been extensively used for cancer relevant clinical applications. In this thesis, a variety of dual-functional polydimethylsiloxane (PDMS)-based chips were developed to achieve both CTC capture and elution, for cancer diagnosis. For therapeutic application, a variety of polyethylene glycol diacrylate (PEGDA) and polyvinylpyrrolidone (PVP) based microneedle patches encapsulating drugs was designed and fabricated to achieve transdermal drug delivery. DOCTOR OF PHILOSOPHY (SCBE) 2015-11-12T07:30:10Z 2015-11-12T07:30:10Z 2015 2015 Thesis Xue, P. (2015). Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/65571 10.32657/10356/65571 en 158 p. application/pdf |
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DRNTU::Engineering::Bioengineering Xue, Peng Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy |
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To complement the traditional silicon and glass-based microfluidic devices, polymer-based microdevices have attracted much more attention in recent years. Advantages of low cost, excellent mechanical property, low demands of facilities and reagents have further facilitated the development of polymer-based microdevices. Simultaneously, novel microfabrication techniques being developed enable the integration of microfluidic chips to achieve multiple analyses on the same chip, especially in the research fields of medical diagnostic assays and clinical therapy. Cancer is a critical disease with high lethal rate nowadays. Diagnostics and therapeutics of cancer are important subjects, and any relevant creativity may change human lives in future. Polymer-based microfluidic microdevices have been extensively used for cancer relevant clinical applications. In this thesis, a variety of dual-functional polydimethylsiloxane (PDMS)-based chips were developed to achieve both CTC capture and elution, for cancer diagnosis. For therapeutic application, a variety of polyethylene glycol diacrylate (PEGDA) and polyvinylpyrrolidone (PVP) based microneedle patches encapsulating drugs was designed and fabricated to achieve transdermal drug delivery. |
author2 |
Kang Yuejun |
author_facet |
Kang Yuejun Xue, Peng |
format |
Theses and Dissertations |
author |
Xue, Peng |
author_sort |
Xue, Peng |
title |
Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy |
title_short |
Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy |
title_full |
Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy |
title_fullStr |
Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy |
title_full_unstemmed |
Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy |
title_sort |
polymer-based biomedical microdevices for ctc diagnosis and keloid therapy |
publishDate |
2015 |
url |
https://hdl.handle.net/10356/65571 |
_version_ |
1759853600087998464 |