Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy

To complement the traditional silicon and glass-based microfluidic devices, polymer-based microdevices have attracted much more attention in recent years. Advantages of low cost, excellent mechanical property, low demands of facilities and reagents have further facilitated the development of polymer...

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Main Author: Xue, Peng
Other Authors: Kang Yuejun
Format: Theses and Dissertations
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/65571
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-655712023-03-03T15:58:00Z Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy Xue, Peng Kang Yuejun School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering To complement the traditional silicon and glass-based microfluidic devices, polymer-based microdevices have attracted much more attention in recent years. Advantages of low cost, excellent mechanical property, low demands of facilities and reagents have further facilitated the development of polymer-based microdevices. Simultaneously, novel microfabrication techniques being developed enable the integration of microfluidic chips to achieve multiple analyses on the same chip, especially in the research fields of medical diagnostic assays and clinical therapy. Cancer is a critical disease with high lethal rate nowadays. Diagnostics and therapeutics of cancer are important subjects, and any relevant creativity may change human lives in future. Polymer-based microfluidic microdevices have been extensively used for cancer relevant clinical applications. In this thesis, a variety of dual-functional polydimethylsiloxane (PDMS)-based chips were developed to achieve both CTC capture and elution, for cancer diagnosis. For therapeutic application, a variety of polyethylene glycol diacrylate (PEGDA) and polyvinylpyrrolidone (PVP) based microneedle patches encapsulating drugs was designed and fabricated to achieve transdermal drug delivery. DOCTOR OF PHILOSOPHY (SCBE) 2015-11-12T07:30:10Z 2015-11-12T07:30:10Z 2015 2015 Thesis Xue, P. (2015). Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/65571 10.32657/10356/65571 en 158 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Xue, Peng
Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy
description To complement the traditional silicon and glass-based microfluidic devices, polymer-based microdevices have attracted much more attention in recent years. Advantages of low cost, excellent mechanical property, low demands of facilities and reagents have further facilitated the development of polymer-based microdevices. Simultaneously, novel microfabrication techniques being developed enable the integration of microfluidic chips to achieve multiple analyses on the same chip, especially in the research fields of medical diagnostic assays and clinical therapy. Cancer is a critical disease with high lethal rate nowadays. Diagnostics and therapeutics of cancer are important subjects, and any relevant creativity may change human lives in future. Polymer-based microfluidic microdevices have been extensively used for cancer relevant clinical applications. In this thesis, a variety of dual-functional polydimethylsiloxane (PDMS)-based chips were developed to achieve both CTC capture and elution, for cancer diagnosis. For therapeutic application, a variety of polyethylene glycol diacrylate (PEGDA) and polyvinylpyrrolidone (PVP) based microneedle patches encapsulating drugs was designed and fabricated to achieve transdermal drug delivery.
author2 Kang Yuejun
author_facet Kang Yuejun
Xue, Peng
format Theses and Dissertations
author Xue, Peng
author_sort Xue, Peng
title Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy
title_short Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy
title_full Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy
title_fullStr Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy
title_full_unstemmed Polymer-based biomedical microdevices for CTC diagnosis and keloid therapy
title_sort polymer-based biomedical microdevices for ctc diagnosis and keloid therapy
publishDate 2015
url https://hdl.handle.net/10356/65571
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