The study of dopamine metabolism with LRRK2 variants in Parkinson’s disease

• Main Author: Kwok, Wei Hao
• Other Authors: Zhao Yi
• Format: Final Year Project
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• Online Access: http://hdl.handle.net/10356/65657
• Institution: Nanyang Technological University

Background: Parkinson's disease (PD) is a neurodegenerative disease in which symptoms typically appear when a loss of dopaminergic (DA) neurons causes dopamine levels to fall significantly. Leucine rich repeat kinase 2 (LRRK2) gene mutations are the most common genetic cause of PD. Dopamine dec...