Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery

Mesoprous silica nanoparticles (MSNPs) are commonly used in the area of drug delivery due to their high surface area, large volume and easy functionalisation. In our study, we aim to improve the design of these MSNPs for drug delivery application. Hence, Chapter 2 utilizes MSNPs that are conjugated...

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Main Author: Tan, Si Yu
Other Authors: Zhao Yanli
Format: Theses and Dissertations
Language:English
Published: 2016
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Online Access:https://hdl.handle.net/10356/65911
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-659112023-02-28T23:53:05Z Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery Tan, Si Yu Zhao Yanli School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Mesoprous silica nanoparticles (MSNPs) are commonly used in the area of drug delivery due to their high surface area, large volume and easy functionalisation. In our study, we aim to improve the design of these MSNPs for drug delivery application. Hence, Chapter 2 utilizes MSNPs that are conjugated with a neuronal cell targeting ligand and the results obtained showed positive uptake into neuronal cells. As the neuronal cell targeting ligand was also known to be expressed in some cancer cell lines, Chapter 3 focuses on the use of this ligand together with the use of anticancer drug, Doxorubicin (DOX), to study their simultaneous effect on B16F10 melanoma cancer cell line and NIH3T3 normal cell line. A synergistic effect was observed when both the ligand and Dox was used. Besides using targeting moieties on MSNPs, the drug loading and release mechanism of MSNPs was optimized with a catalysis screening method in Chapter 4. It was concluded that moderate chain length with intermediately bulky terminal group and low density of disulfide-appended functional ligands on the surface of MSNPs gave the best drug release profiles. In conclusion, the above methods have a common goal of improving the drug delivery efficiency of MSNPs. DOCTOR OF PHILOSOPHY (SPMS) 2016-01-14T07:56:19Z 2016-01-14T07:56:19Z 2016 Thesis Tan, S. Y. (2016). Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/65911 10.32657/10356/65911 en 160 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry
spellingShingle DRNTU::Science::Chemistry
Tan, Si Yu
Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery
description Mesoprous silica nanoparticles (MSNPs) are commonly used in the area of drug delivery due to their high surface area, large volume and easy functionalisation. In our study, we aim to improve the design of these MSNPs for drug delivery application. Hence, Chapter 2 utilizes MSNPs that are conjugated with a neuronal cell targeting ligand and the results obtained showed positive uptake into neuronal cells. As the neuronal cell targeting ligand was also known to be expressed in some cancer cell lines, Chapter 3 focuses on the use of this ligand together with the use of anticancer drug, Doxorubicin (DOX), to study their simultaneous effect on B16F10 melanoma cancer cell line and NIH3T3 normal cell line. A synergistic effect was observed when both the ligand and Dox was used. Besides using targeting moieties on MSNPs, the drug loading and release mechanism of MSNPs was optimized with a catalysis screening method in Chapter 4. It was concluded that moderate chain length with intermediately bulky terminal group and low density of disulfide-appended functional ligands on the surface of MSNPs gave the best drug release profiles. In conclusion, the above methods have a common goal of improving the drug delivery efficiency of MSNPs.
author2 Zhao Yanli
author_facet Zhao Yanli
Tan, Si Yu
format Theses and Dissertations
author Tan, Si Yu
author_sort Tan, Si Yu
title Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery
title_short Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery
title_full Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery
title_fullStr Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery
title_full_unstemmed Rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery
title_sort rational surface functionalization on mesoporous silica nanoparticles for targeted and controlled drug delivery
publishDate 2016
url https://hdl.handle.net/10356/65911
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