Investigation of biodegradable magnesium based esophageal stent
A fully biodegradable metallic esophageal stent implantation is an ideal treatment for preventing occlusion and narrowing of the human esophagus, particularly in benign esophageal diseases condition. The most important advantage is the removal of the need for a second surgical intervention to rem...
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| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/65959 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | A fully biodegradable metallic esophageal stent implantation is an ideal treatment for
preventing occlusion and narrowing of the human esophagus, particularly in benign
esophageal diseases condition. The most important advantage is the removal of the
need for a second surgical intervention to remove an implanted stent. It also
demonstrates the potential advantage in mechanical strength and anti-migration
features. Until recently, there is still a lack of understanding of the performance of the
biodegradable magnesium alloy esophageal stent either in vitro or in vivo. To achieve
better understanding, this project investigates the degradation behaviors of the
magnesium alloy in simulated static chemical environment of esophagus in vitro and
the degradation behaviors and biocompatibility of a magnesium alloy stent in vivo, i.e.
in pig model. A pseudo-esophageal test system simulating the critical esophageal
environmental conditions for systematic development of metallic esophageal stent
with degradation controllability feature is developed. |
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