Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer
Breast cancer remains curable until the metastatic cancer cells disseminate beyond the regional lymph nodes. The 5-year relative survival rate of stage IV breast cancer is less than 22%. Therefore, strategies to prevent the dissemination of breast cancer cells into bloodstream, eliminate the circula...
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sg-ntu-dr.10356-659772023-03-03T16:04:56Z Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer Fu, Afu School of Chemical and Biomedical Engineering Qian Luo, Kathy DRNTU::Engineering::Bioengineering Breast cancer remains curable until the metastatic cancer cells disseminate beyond the regional lymph nodes. The 5-year relative survival rate of stage IV breast cancer is less than 22%. Therefore, strategies to prevent the dissemination of breast cancer cells into bloodstream, eliminate the circulating tumor cells (CTCs), or suppress the proliferation of disseminated tumor cells (DTCs), can potentially inhibit cancer progression and improve the survival of breast cancer patients. So far, the mechanisms of how hemodynamic shear force induces apoptosis of CTCs and how metastatic breast cancer cell manage to survive in blood circulation are still unclear. Therefore, this thesis focused on the survival mechanisms of CTCs and aims to identify functional biomarkers and develop therapeutic strategies for metastatic breast cancer. DOCTOR OF PHILOSOPHY (SCBE) 2016-02-11T08:23:32Z 2016-02-11T08:23:32Z 2016 Thesis Fu, A. (2016). Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/65977 10.32657/10356/65977 en 251 p. application/pdf |
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DRNTU::Engineering::Bioengineering Fu, Afu Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer |
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Breast cancer remains curable until the metastatic cancer cells disseminate beyond the regional lymph nodes. The 5-year relative survival rate of stage IV breast cancer is less than 22%. Therefore, strategies to prevent the dissemination of breast cancer cells into bloodstream, eliminate the circulating tumor cells (CTCs), or suppress the proliferation of disseminated tumor cells (DTCs), can potentially inhibit cancer progression and improve the survival of breast cancer patients. So far, the mechanisms of how hemodynamic shear force induces apoptosis of CTCs and how metastatic breast cancer cell manage to survive in blood circulation are still unclear. Therefore, this thesis focused on the survival mechanisms of CTCs and aims to identify functional biomarkers and develop therapeutic strategies for metastatic breast cancer. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Fu, Afu |
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Theses and Dissertations |
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Fu, Afu |
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Fu, Afu |
title |
Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer |
title_short |
Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer |
title_full |
Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer |
title_fullStr |
Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer |
title_full_unstemmed |
Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer |
title_sort |
study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer |
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2016 |
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https://hdl.handle.net/10356/65977 |
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