Unravelling the roles of non-Watson-Crick and triplex structures in regulating RNA folding dynamics and function

• Main Author: Zhong, Zhensheng
• Other Authors: Chen Gang
• Format: Theses and Dissertations
• Language: English
• Published: 2016
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/66532
• Institution: Nanyang Technological University

It is not well understood how the RNA folding and unfolding dynamics, mechanical properties, and biological functions are affected by non-Watson-Crick pairs and base triples. Using a human telomerase RNA hairpin containing four consecutive non-canonical base pairs as a model system, we studied the e...