Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes

Acne Vulgaris is a common chronic skin inflammatory disorder caused by inflammation of the hair follicles and sebaceous glands of the skin, affecting millions of individuals worldwide. The presence of Priopionibacterium acnes (P. acnes) has been implicated as a major feature of Acne Vulgaris by its...

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Main Author: Chan, Hanna Wan Mun
Other Authors: Baptiste Janela
Format: Final Year Project
Language:English
Published: 2016
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Online Access:http://hdl.handle.net/10356/67156
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-671562023-02-28T18:05:12Z Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes Chan, Hanna Wan Mun Baptiste Janela School of Biological Sciences A*STAR Singapore Immunology Network DRNTU::Science::Biological sciences DRNTU::Science::Biological sciences::Microbiology::Immunology Acne Vulgaris is a common chronic skin inflammatory disorder caused by inflammation of the hair follicles and sebaceous glands of the skin, affecting millions of individuals worldwide. The presence of Priopionibacterium acnes (P. acnes) has been implicated as a major feature of Acne Vulgaris by its induction and maintenance of inflammatory conditions. Using a murine model of P. acnes infection, we characterise the contribution of lymphoid cells in the immune response to P. acnes and assess the role of Langerin-expressing DCs in the regulation of skin infiltrating immune cell recruitment. Our data show that in response to P. acnes, the αβ T and B lymphocytes expand in the skin-draining lymph node, suggesting a major activation of the immune response. This activation is translated by accumulation of T lymphocytes and ILCs in the skin. The depletion of Langerinexpressing DCs, which reportedly controls the innate immune response to P. acnes, significantly reduced cellularities in the skin-draining lymph node. However, the accumulation of T cells and ILCs in the skin is unaffected by the ablation of Langerin-expressing DCs. Together, these results may indicate that the role of Langerin-expressing DCs is differentially regulated in tissues in response to P. acnes. Remove Bachelor of Science in Biological Sciences 2016-05-12T04:56:19Z 2016-05-12T04:56:19Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/67156 en Nanyang Technological University 38 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences
DRNTU::Science::Biological sciences::Microbiology::Immunology
spellingShingle DRNTU::Science::Biological sciences
DRNTU::Science::Biological sciences::Microbiology::Immunology
Chan, Hanna Wan Mun
Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes
description Acne Vulgaris is a common chronic skin inflammatory disorder caused by inflammation of the hair follicles and sebaceous glands of the skin, affecting millions of individuals worldwide. The presence of Priopionibacterium acnes (P. acnes) has been implicated as a major feature of Acne Vulgaris by its induction and maintenance of inflammatory conditions. Using a murine model of P. acnes infection, we characterise the contribution of lymphoid cells in the immune response to P. acnes and assess the role of Langerin-expressing DCs in the regulation of skin infiltrating immune cell recruitment. Our data show that in response to P. acnes, the αβ T and B lymphocytes expand in the skin-draining lymph node, suggesting a major activation of the immune response. This activation is translated by accumulation of T lymphocytes and ILCs in the skin. The depletion of Langerinexpressing DCs, which reportedly controls the innate immune response to P. acnes, significantly reduced cellularities in the skin-draining lymph node. However, the accumulation of T cells and ILCs in the skin is unaffected by the ablation of Langerin-expressing DCs. Together, these results may indicate that the role of Langerin-expressing DCs is differentially regulated in tissues in response to P. acnes. Remove
author2 Baptiste Janela
author_facet Baptiste Janela
Chan, Hanna Wan Mun
format Final Year Project
author Chan, Hanna Wan Mun
author_sort Chan, Hanna Wan Mun
title Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes
title_short Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes
title_full Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes
title_fullStr Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes
title_full_unstemmed Impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to Propionibacterium acnes
title_sort impact of cutaneous dendritic cell subsets on the evolution of lymphoid cells in response to propionibacterium acnes
publishDate 2016
url http://hdl.handle.net/10356/67156
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