Lipid disequilibrium destabilized a subset of membrane proteins

• Main Author: Chaw, Rui Jie
• Other Authors: Guillaume Thibault
• Format: Final Year Project
• Language: English
• Published: 2016
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/67182
• Institution: Nanyang Technological University

Imbalance between the major membrane phospholipids, phosphatidylcholine and phosphatidylethanolamine, has been implicated in several disease states. In yeast cells under membrane lipid disequilibrium, protein levels of Sbh1, a subunit of the Sec61 translocon complex, is decreased. A MYTH screen for...