Paper-based microfluidic device : serial dilution application

Recently, there is an increasing demand in point-of-care diagnostic devices in the healthcare industry. Statistics show that such devices have high accuracy and can reduce diagnosis time significantly. Using paper-based microfluidic devices as diagnostic tools offers the benefits of being cheap and...

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Main Author: Tan, Eng Kiat
Other Authors: Li King Ho Holden
Format: Final Year Project
Language:English
Published: 2016
Subjects:
Online Access:http://hdl.handle.net/10356/67241
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-672412023-03-04T19:14:32Z Paper-based microfluidic device : serial dilution application Tan, Eng Kiat Li King Ho Holden School of Mechanical and Aerospace Engineering DRNTU::Engineering Recently, there is an increasing demand in point-of-care diagnostic devices in the healthcare industry. Statistics show that such devices have high accuracy and can reduce diagnosis time significantly. Using paper-based microfluidic devices as diagnostic tools offers the benefits of being cheap and great portability and able to use it in low resource environment. The research objective is to develop a paper-based microfluidic device for serial dilution application, which is usually the initial stage in diagnosing of diseases. Current serial dilution practice is through manual pipetting, and is a time consuming task. Extensive literature review covers the fundamentals of paper-based microfluidic and currently available techniques. Characterization of paper and fluid flow in paper had been covered to give better understanding in the wicking process. The paper circuit designed in this study was based on several experimental results and observations, with the concentration of fluid in the circuit calculated by image analysis using ImageJ. The final design of the paper-based serial dilution circuit gives the user a pre-defined dilution factor. Future development includes integrating with electrochemistry technology which is able to provide measurements and act as a sensor to detect certain content in the fluid. This will greatly enhance the capability of diagnosis of diseases in the healthcare industry. Bachelor of Engineering (Mechanical Engineering) 2016-05-13T03:39:16Z 2016-05-13T03:39:16Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/67241 en Nanyang Technological University 61 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering
spellingShingle DRNTU::Engineering
Tan, Eng Kiat
Paper-based microfluidic device : serial dilution application
description Recently, there is an increasing demand in point-of-care diagnostic devices in the healthcare industry. Statistics show that such devices have high accuracy and can reduce diagnosis time significantly. Using paper-based microfluidic devices as diagnostic tools offers the benefits of being cheap and great portability and able to use it in low resource environment. The research objective is to develop a paper-based microfluidic device for serial dilution application, which is usually the initial stage in diagnosing of diseases. Current serial dilution practice is through manual pipetting, and is a time consuming task. Extensive literature review covers the fundamentals of paper-based microfluidic and currently available techniques. Characterization of paper and fluid flow in paper had been covered to give better understanding in the wicking process. The paper circuit designed in this study was based on several experimental results and observations, with the concentration of fluid in the circuit calculated by image analysis using ImageJ. The final design of the paper-based serial dilution circuit gives the user a pre-defined dilution factor. Future development includes integrating with electrochemistry technology which is able to provide measurements and act as a sensor to detect certain content in the fluid. This will greatly enhance the capability of diagnosis of diseases in the healthcare industry.
author2 Li King Ho Holden
author_facet Li King Ho Holden
Tan, Eng Kiat
format Final Year Project
author Tan, Eng Kiat
author_sort Tan, Eng Kiat
title Paper-based microfluidic device : serial dilution application
title_short Paper-based microfluidic device : serial dilution application
title_full Paper-based microfluidic device : serial dilution application
title_fullStr Paper-based microfluidic device : serial dilution application
title_full_unstemmed Paper-based microfluidic device : serial dilution application
title_sort paper-based microfluidic device : serial dilution application
publishDate 2016
url http://hdl.handle.net/10356/67241
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