Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology

Liver biopsy involves the needle extraction of a small suspicious lesion liver tissue for diagnosis which leaves behind a tract cavity in the liver site. In more fatal complications it will result in severe haemorrhage and as such tract embolization is commonly employed as a post biopsy procedure to...

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Main Author: Tan, Pei Leng
Other Authors: Subramanian Venkatraman
Format: Final Year Project
Language:English
Published: 2016
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Online Access:http://hdl.handle.net/10356/67631
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-676312023-03-04T15:30:47Z Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology Tan, Pei Leng Subramanian Venkatraman School of Materials Science and Engineering DRNTU::Engineering::Materials::Biomaterials Liver biopsy involves the needle extraction of a small suspicious lesion liver tissue for diagnosis which leaves behind a tract cavity in the liver site. In more fatal complications it will result in severe haemorrhage and as such tract embolization is commonly employed as a post biopsy procedure to minimize the occurrence of haemorrhage or for haemostatic purposes in cases of haemorrhage. Gelfoam sponge is the only available biodegradable embolic agent used for embolization. However, it is associated with major limitations such as non-targeted occlusion, complicated preparation and application of the Gelfoam sponge. A novel biodegradable injectable polymer, Pluronic F127, was proposed as a substitute for Gelfoam to enhance the ease of embolization. It was hypothesised that the thermal responsive mechanism of Pluronic F127 can actuate the device at physiological temperature upon contact with blood and embolize tract cavity. Hence the rheological characteristics of increasing amount of Pluronic F127 were studied to determine the optimal concentration for such application. Following which the effects of increasing concentrations of radiopaque mediums on mechanical properties of the Pluronic F127 polymer were explored to determine an optimal formulation of 19% Pluronic F127 with 30% barium sulphate for a high storage modulus embolic device. A simple and effective tilt method was conducted under different heating condition to substantiate the thermal responsivity mechanism of the device. The device was injected into flow model tract cavities to study the in-vitro viability of Pluronic F127 polymer as an injectable embolic device. The in-vitro flow test exhibited a 100% occlusion instantaneously with full dissolution after 23 minutes. These results have demonstrated the potential on the use of injectable thermal-responsive Pluronic polymer as a future bioresorbable injectable hydrogel for temporary tract embolization. Bachelor of Engineering (Materials Engineering) 2016-05-18T08:35:47Z 2016-05-18T08:35:47Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/67631 en Nanyang Technological University 43 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials::Biomaterials
spellingShingle DRNTU::Engineering::Materials::Biomaterials
Tan, Pei Leng
Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology
description Liver biopsy involves the needle extraction of a small suspicious lesion liver tissue for diagnosis which leaves behind a tract cavity in the liver site. In more fatal complications it will result in severe haemorrhage and as such tract embolization is commonly employed as a post biopsy procedure to minimize the occurrence of haemorrhage or for haemostatic purposes in cases of haemorrhage. Gelfoam sponge is the only available biodegradable embolic agent used for embolization. However, it is associated with major limitations such as non-targeted occlusion, complicated preparation and application of the Gelfoam sponge. A novel biodegradable injectable polymer, Pluronic F127, was proposed as a substitute for Gelfoam to enhance the ease of embolization. It was hypothesised that the thermal responsive mechanism of Pluronic F127 can actuate the device at physiological temperature upon contact with blood and embolize tract cavity. Hence the rheological characteristics of increasing amount of Pluronic F127 were studied to determine the optimal concentration for such application. Following which the effects of increasing concentrations of radiopaque mediums on mechanical properties of the Pluronic F127 polymer were explored to determine an optimal formulation of 19% Pluronic F127 with 30% barium sulphate for a high storage modulus embolic device. A simple and effective tilt method was conducted under different heating condition to substantiate the thermal responsivity mechanism of the device. The device was injected into flow model tract cavities to study the in-vitro viability of Pluronic F127 polymer as an injectable embolic device. The in-vitro flow test exhibited a 100% occlusion instantaneously with full dissolution after 23 minutes. These results have demonstrated the potential on the use of injectable thermal-responsive Pluronic polymer as a future bioresorbable injectable hydrogel for temporary tract embolization.
author2 Subramanian Venkatraman
author_facet Subramanian Venkatraman
Tan, Pei Leng
format Final Year Project
author Tan, Pei Leng
author_sort Tan, Pei Leng
title Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology
title_short Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology
title_full Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology
title_fullStr Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology
title_full_unstemmed Bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology
title_sort bioresorbable thermo-responsible injectable hydrogel for temporary tract embolization in interventional radiology
publishDate 2016
url http://hdl.handle.net/10356/67631
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