Novel therapeutic approach for cutaneous T-Cell lymphoma

• Main Author: Low, Jian Hui
• Other Authors: Navin Kumar Verma
• Format: Final Year Project
• Language: English
• Published: 2016
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/68186
• Institution: Nanyang Technological University

Cutaneous T-cell lymphoma (CTCL) is a skin-localizing, non-Hodgkin lymphoma arising from the malignant transformation of skin-homing CD4+ T-cells. The primary drivers of CTCL pathogenesis is aberrant signalling of the JAK/STAT3 pathway, resulting in defective apoptosis and increased cellular prolife...