Monte Carlo modeling of optical coherence tomography in biological tissue with embedded object

• Main Author: Ng, See Mui
• Other Authors: Manojit Pramanik
• Format: Final Year Project
• Language: English
• Published: 2016
• Subjects: DRNTU::Engineering
• Online Access: http://hdl.handle.net/10356/68424
• Institution: Nanyang Technological University

Optical scattering and absorption characterize light transport in biological tissue. A popular technique used to study light-tissue interaction is the Monte Carlo simulation. However, Monte Carlo modeling with different geometry has not been widely studied. By integrating embedded objects into Monte Carlo multi-layered structure, it provides a more realistic tissue structure. In this project, time-domain OCT simulation for multi- layered tissue with four types of embedded objects (i.e. sphere, cylinder, ellipsoid, and cuboid) was performed. Improved importance sampling (IS) was carried out to accelerate the OCT simulation. IS was validated against standard and angle biased Monte Carlo method for OCT. Coherency was observed for class I and class II photons in all three methods. The only difference is that IS method has more than ten-fold improvement in the simulation time. B-scan images were obtained for four types of embedded objects and all the four objects are distinctly noticeable from the B-scan OCT images. By using improved IS, B-scan OCT images can be attained under an acceptable simulation time. The Monte Carlo modeling of OCT in biological tissue with embedded object is user- friendly which will be useful in many biological applications. Although there is improvement in the simulation time with IS method, OCT simulation time can further be accelerated with the aid of graphics processing unit.