The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection

Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent Plasmodium yoelii strains, we investigated how parasite virulence modulates overall spleen function. Following parasite invasion, a differen...

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Main Author: Huang, Ximei
Other Authors: Peter Rainer Preiser
Format: Theses and Dissertations
Language:English
Published: 2016
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Online Access:https://hdl.handle.net/10356/69005
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-690052023-02-28T18:49:03Z The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection Huang, Ximei Peter Rainer Preiser School of Biological Sciences DRNTU::Science::Biological sciences::Molecular biology Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent Plasmodium yoelii strains, we investigated how parasite virulence modulates overall spleen function. Following parasite invasion, a difference in parasite virulence and the corresponding disease outcome was observed to associate with different spleen morphology, immune response and iRBC rigidity, all of which contributing to enhanced parasite clearance. The iRBC rigidity as modulated by the spleen was demonstrated to regulate disease outcome. Moreover, the early activation of pro-inflammatory responses in the spleen appears to help to control the parasite development, confirming that early spleen responses are a key factor in directing the clinical outcome of an infection. This work highlights the biological responses to control malaria disease development, and also provides a potential tool for fast and easy diagnosis and prognosis of malaria patients. DOCTOR OF PHILOSOPHY (SBS) 2016-08-26T03:59:19Z 2016-08-26T03:59:19Z 2016 Thesis Huang, X. (2016). The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/69005 10.32657/10356/69005 en 200 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Molecular biology
spellingShingle DRNTU::Science::Biological sciences::Molecular biology
Huang, Ximei
The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection
description Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent Plasmodium yoelii strains, we investigated how parasite virulence modulates overall spleen function. Following parasite invasion, a difference in parasite virulence and the corresponding disease outcome was observed to associate with different spleen morphology, immune response and iRBC rigidity, all of which contributing to enhanced parasite clearance. The iRBC rigidity as modulated by the spleen was demonstrated to regulate disease outcome. Moreover, the early activation of pro-inflammatory responses in the spleen appears to help to control the parasite development, confirming that early spleen responses are a key factor in directing the clinical outcome of an infection. This work highlights the biological responses to control malaria disease development, and also provides a potential tool for fast and easy diagnosis and prognosis of malaria patients.
author2 Peter Rainer Preiser
author_facet Peter Rainer Preiser
Huang, Ximei
format Theses and Dissertations
author Huang, Ximei
author_sort Huang, Ximei
title The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection
title_short The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection
title_full The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection
title_fullStr The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection
title_full_unstemmed The role of the spleen in mediating pathology in Plasmodium Yoelii (P.yoelii) infection
title_sort role of the spleen in mediating pathology in plasmodium yoelii (p.yoelii) infection
publishDate 2016
url https://hdl.handle.net/10356/69005
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