Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18)
The cell adhesion molecules integrins are important in immune homeostasis. Dysfunctional or deregulated integrins can lead to a compromised immune system or generate overt inflammatory responses. Apart from its well-established role as a phagocytic receptor, the myeloid specific integrin αMβ2 (CD11b...
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sg-ntu-dr.10356-696282023-02-28T18:51:35Z Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18) Ong, Li Teng Tan Suet Mien School of Biological Sciences DRNTU::Science::Biological sciences The cell adhesion molecules integrins are important in immune homeostasis. Dysfunctional or deregulated integrins can lead to a compromised immune system or generate overt inflammatory responses. Apart from its well-established role as a phagocytic receptor, the myeloid specific integrin αMβ2 (CD11bCD18) is involved in cell migration, leukocyte survival and immune tolerance. We are therefore interested to study the signaling conduits of integrin αMβ2 and determine the roles of the integrin αMβ2 cytoplasmic tails in these events. Herein, we showed for the first time a Systemic Lupus Erythematosus associated single nucleotide polymorphism on integrin αMβ2, SNP rs1143678, exhibits pro-inflammatory properties and it generates a non-canonical docking site in integrin αM cytoplasmic tail for 14-3-3ζ. We also identified RGS10 as a possible integrin αMβ2 downstream signaling target. Finally, we generated kindlin-3 knockdown macrophages to study its regulation of integrin αMβ2 signaling in inflammation. Doctor of Philosophy (SBS) 2017-03-11T06:12:07Z 2017-03-11T06:12:07Z 2017 Thesis Ong, L. T. (2017). Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18). Doctoral thesis, Nanyang Technological University, Singapore. http://hdl.handle.net/10356/69628 10.32657/10356/69628 en 163 p. application/pdf |
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DRNTU::Science::Biological sciences Ong, Li Teng Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18) |
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The cell adhesion molecules integrins are important in immune homeostasis. Dysfunctional or deregulated integrins can lead to a compromised immune system or generate overt inflammatory responses. Apart from its well-established role as a phagocytic receptor, the myeloid specific integrin αMβ2 (CD11bCD18) is involved in cell migration, leukocyte survival and immune tolerance. We are therefore interested to study the signaling conduits of integrin αMβ2 and determine the roles of the integrin αMβ2 cytoplasmic tails in these events. Herein, we showed for the first time a Systemic Lupus Erythematosus associated single nucleotide polymorphism on integrin αMβ2, SNP rs1143678, exhibits pro-inflammatory properties and it generates a non-canonical docking site in integrin αM cytoplasmic tail for 14-3-3ζ. We also identified RGS10 as a possible integrin αMβ2 downstream signaling target. Finally, we generated kindlin-3 knockdown macrophages to study its regulation of integrin αMβ2 signaling in inflammation. |
author2 |
Tan Suet Mien |
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Tan Suet Mien Ong, Li Teng |
format |
Theses and Dissertations |
author |
Ong, Li Teng |
author_sort |
Ong, Li Teng |
title |
Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18) |
title_short |
Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18) |
title_full |
Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18) |
title_fullStr |
Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18) |
title_full_unstemmed |
Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18) |
title_sort |
investigating the signaling properties of myeloid specific integrin αmβ2 (cd11bcd18) |
publishDate |
2017 |
url |
http://hdl.handle.net/10356/69628 |
_version_ |
1759858413418840064 |