Computational studies of the mechanisms of chemical reactions involved in mechanism-based inactivation of cytochrome P450 enzymes
The cytochrome P450 enzymes (P450s) play crucial roles in xenobiotic metabolism, especially drug metabolism. Even though metabolism is fundamentally an essential process, metabolic products could also lead to adverse effects. For example, in mechanism-based inactivation (MBI), a reactive metabolite...
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| 格式: | Theses and Dissertations |
| 語言: | English |
| 出版: |
2017
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| 在線閱讀: | http://hdl.handle.net/10356/69910 |
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| 機構: | Nanyang Technological University |
| 語言: | English |