Biomolecular hydration in protein-protein interaction, protein stability and aggregation and lead optimization : computational studies

• 主要作者: Mohan Rajan Pradhan
• 其他作者: Chandra Shekhar Verma
• 格式: Theses and Dissertations
• 語言: English
• 出版: 2017
• 主題: DRNTU::Engineering::Computer science and engineering::Computer applications::Life and medical sciences
• 在線閱讀: http://hdl.handle.net/10356/69994
• 機構: Nanyang Technological University

The role of intracellular water in biomolecular function is well recognized and yet quantifying this is challenging. This is largely because protein hydration is extremely sensitive to the protein surface chemistry and topology and also to the environmental conditions. This makes protein hydration...