Inference of homology by Blast visualization of influenza genome set

The Spanish Flu, a strain of the influenza virus H1N1, is estimated to have killed 50-100 million people in the 1918 influenza pandemic. Studies have shown that this is a very pathogenic strain of human influenza whereby gene segments have persisted in new reassortant strains, threatening to cause g...

Full description

Saved in:
Bibliographic Details
Main Author: Tan, Jun Qiu
Other Authors: Kwoh Chee Keong
Format: Final Year Project
Language:English
Published: 2017
Subjects:
Online Access:http://hdl.handle.net/10356/70492
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-70492
record_format dspace
spelling sg-ntu-dr.10356-704922023-03-03T20:40:21Z Inference of homology by Blast visualization of influenza genome set Tan, Jun Qiu Kwoh Chee Keong School of Computer Science and Engineering DRNTU::Engineering::Computer science and engineering The Spanish Flu, a strain of the influenza virus H1N1, is estimated to have killed 50-100 million people in the 1918 influenza pandemic. Studies have shown that this is a very pathogenic strain of human influenza whereby gene segments have persisted in new reassortant strains, threatening to cause great harm to public health. Knowledge of the ancestral history/homology of such new reassortant strains can help shed light on understanding how these new strains came to be which may help researchers develop new insights in preventing the spread of future influenza pandemics. Sequence similarity analysis through BLAST is one of the first few steps to understanding sequence homology but current BLAST visualizations can be intimidating and confusing. The aim of this project is to develop a web application that improves upon current BLAST visualizations by filtering results based on year and summarizing additional supplementary data from BLAST hits (Country, Host, Year, Segment) into insightful charts that provide a quick overview of the results that BLAST has created. This would provide users with sufficient background knowledge for better inference about the sequence homology of the query Influenza genome set as well as potentially assisting in the development of insightful hypotheses. Bachelor of Engineering (Computer Science) 2017-04-25T06:50:22Z 2017-04-25T06:50:22Z 2017 Final Year Project (FYP) http://hdl.handle.net/10356/70492 en Nanyang Technological University 69 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Computer science and engineering
spellingShingle DRNTU::Engineering::Computer science and engineering
Tan, Jun Qiu
Inference of homology by Blast visualization of influenza genome set
description The Spanish Flu, a strain of the influenza virus H1N1, is estimated to have killed 50-100 million people in the 1918 influenza pandemic. Studies have shown that this is a very pathogenic strain of human influenza whereby gene segments have persisted in new reassortant strains, threatening to cause great harm to public health. Knowledge of the ancestral history/homology of such new reassortant strains can help shed light on understanding how these new strains came to be which may help researchers develop new insights in preventing the spread of future influenza pandemics. Sequence similarity analysis through BLAST is one of the first few steps to understanding sequence homology but current BLAST visualizations can be intimidating and confusing. The aim of this project is to develop a web application that improves upon current BLAST visualizations by filtering results based on year and summarizing additional supplementary data from BLAST hits (Country, Host, Year, Segment) into insightful charts that provide a quick overview of the results that BLAST has created. This would provide users with sufficient background knowledge for better inference about the sequence homology of the query Influenza genome set as well as potentially assisting in the development of insightful hypotheses.
author2 Kwoh Chee Keong
author_facet Kwoh Chee Keong
Tan, Jun Qiu
format Final Year Project
author Tan, Jun Qiu
author_sort Tan, Jun Qiu
title Inference of homology by Blast visualization of influenza genome set
title_short Inference of homology by Blast visualization of influenza genome set
title_full Inference of homology by Blast visualization of influenza genome set
title_fullStr Inference of homology by Blast visualization of influenza genome set
title_full_unstemmed Inference of homology by Blast visualization of influenza genome set
title_sort inference of homology by blast visualization of influenza genome set
publishDate 2017
url http://hdl.handle.net/10356/70492
_version_ 1759857619334332416