Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses

Withania coagulans Dunal is a plant that is native to the Asia-temperate and Asiatropical regions. It is used in the traditional system of medicine and reported to possess a multitude of medicinal benefits. Given the adverse side effects and disease resistance observed for current drugs, there is...

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Main Author: Saburnisha Mohamad Raffi
Other Authors: Loo Say Chye Joachim
Format: Final Year Project
Language:English
Published: 2017
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Online Access:http://hdl.handle.net/10356/70980
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-709802023-03-04T15:38:33Z Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses Saburnisha Mohamad Raffi Loo Say Chye Joachim School of Materials Science and Engineering DRNTU::Engineering::Materials Withania coagulans Dunal is a plant that is native to the Asia-temperate and Asiatropical regions. It is used in the traditional system of medicine and reported to possess a multitude of medicinal benefits. Given the adverse side effects and disease resistance observed for current drugs, there is an increased thrust in the development of natural, plant-derived therapeutic molecules as an alternative. Withania coagulans is one such plant with proven therapeutic effects. This study aims to focus on the wound healing and anti-cancer properties of Withania coagulans, by extracting a concentrated form of the phytocompounds from the berries and encapsulating it in polymeric carriers to achieve a controlled and sustained release system. The phytocompounds were extracted using organic solvents and then encapsulated into PLGA of different molecular weights. The encapsulation and release of the phytocompounds from polymeric microparticles of varying molecular weights was analysed. The degradation of the PLGA microparticles over time was also studied. It is evident from the studies that the phytocompounds can be successfully encapsulated in PLGA microparticles and a controlled sustained release can be achieved. Some of the preliminary in vitro testing of the therapeutic effects of the phytocompounds also show a promising direction for the use of the extracts. Detailed studies would be carried out in the future to prove the wound healing and anti-cancer properties of the extract on cells and also the efficacy of the carrier system for such applications. Bachelor of Engineering (Materials Engineering) 2017-05-12T06:06:10Z 2017-05-12T06:06:10Z 2017 Final Year Project (FYP) http://hdl.handle.net/10356/70980 en Nanyang Technological University 42 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials
spellingShingle DRNTU::Engineering::Materials
Saburnisha Mohamad Raffi
Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses
description Withania coagulans Dunal is a plant that is native to the Asia-temperate and Asiatropical regions. It is used in the traditional system of medicine and reported to possess a multitude of medicinal benefits. Given the adverse side effects and disease resistance observed for current drugs, there is an increased thrust in the development of natural, plant-derived therapeutic molecules as an alternative. Withania coagulans is one such plant with proven therapeutic effects. This study aims to focus on the wound healing and anti-cancer properties of Withania coagulans, by extracting a concentrated form of the phytocompounds from the berries and encapsulating it in polymeric carriers to achieve a controlled and sustained release system. The phytocompounds were extracted using organic solvents and then encapsulated into PLGA of different molecular weights. The encapsulation and release of the phytocompounds from polymeric microparticles of varying molecular weights was analysed. The degradation of the PLGA microparticles over time was also studied. It is evident from the studies that the phytocompounds can be successfully encapsulated in PLGA microparticles and a controlled sustained release can be achieved. Some of the preliminary in vitro testing of the therapeutic effects of the phytocompounds also show a promising direction for the use of the extracts. Detailed studies would be carried out in the future to prove the wound healing and anti-cancer properties of the extract on cells and also the efficacy of the carrier system for such applications.
author2 Loo Say Chye Joachim
author_facet Loo Say Chye Joachim
Saburnisha Mohamad Raffi
format Final Year Project
author Saburnisha Mohamad Raffi
author_sort Saburnisha Mohamad Raffi
title Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses
title_short Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses
title_full Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses
title_fullStr Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses
title_full_unstemmed Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses
title_sort extraction and encapsulation of phytocompounds from withania coagulans for therapeutic uses
publishDate 2017
url http://hdl.handle.net/10356/70980
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