Development of therapeutic antibodies against SIRPα

• Main Author: Chan, Lynn Xing Hui
• Other Authors: Par Nordlund
• Format: Final Year Project
• Language: English
• Published: 2017
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/71532
• Institution: Nanyang Technological University

Cancer can evade detection by the immune system through interactions with effector cells such as macrophages. CD47 acts as a “don’t eat me” signal for normal cells and is overexpressed in many cancer types. CD47 interacts with SIRPα on macrophages and inhibits phagocytosis. Disrupting the CD47-SIRPα...