3D/2D rodent brain extraction using shape model and instance learning

• Main Author: Ling, Chen
• Other Authors: Lin Zhiping
• Format: Final Year Project
• Language: English
• Published: 2017
• Subjects: DRNTU::Engineering::Electrical and electronic engineering
• Online Access: http://hdl.handle.net/10356/72200
• Institution: Nanyang Technological University

Accurate rodent brain extraction is one of the basic steps for many translational study using Magnetic Resonance Imaging (MRI). In this report, we present a new approach to model the rodent brain variation using non-rigid B-spline image registration for the brain extraction in MRI images. We model the shape and appearance with the B-spline parameters together with a mean brain image. Followed by a method using multi-expert, we refine the brain extraction region. Compared with the image-based template model using cross-correlation, the performance for rodent brain extraction has shown much improvement on one data set while maintaining the similar yet more consistent performance for another. Both template based methods however outperform the voxel based method (3D PCNN) and a modified BET version for rodent brain extraction.