Evaluation of carrier properties for dry powder inhalation applications

Dry powder inhalation (DPI) formulations have been playing a critical part to increase the effectiveness of dry-powder delivery for inhalation. Most DPI formulations are composed of micron-size drug mixed with larger carrier particles, which are capable of diminishing aggregation, and aid in dispers...

Full description

Saved in:
Bibliographic Details
Main Author: Nguyen, Thi Quynh Ngoc
Other Authors: Lau Wai Man
Format: Theses and Dissertations
Language:English
Published: 2017
Subjects:
Online Access:http://hdl.handle.net/10356/72365
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-72365
record_format dspace
spelling sg-ntu-dr.10356-723652023-03-03T16:02:45Z Evaluation of carrier properties for dry powder inhalation applications Nguyen, Thi Quynh Ngoc Lau Wai Man School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering Dry powder inhalation (DPI) formulations have been playing a critical part to increase the effectiveness of dry-powder delivery for inhalation. Most DPI formulations are composed of micron-size drug mixed with larger carrier particles, which are capable of diminishing aggregation, and aid in dispersion. Moreover, the performance of carrier-based DPI formulations is highly dependent upon interactions between the drug and the carrier particles. A combination of many factors such as particle size, shape, surface area, and morphology give an influence to the drug-carrier interaction forces and aerodynamic properties. In addition to those above factors, carrier surface properties play a key part in the dispersion and deposition of DPI formulations. This dissertation mainly focuses on investigating the effect of carrier surface characteristics in vitro deposition and drug-carrier particles interaction. ​Master of Science (Biomedical Engineering) 2017-06-16T03:34:00Z 2017-06-16T03:34:00Z 2017 Thesis http://hdl.handle.net/10356/72365 en 59 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Nguyen, Thi Quynh Ngoc
Evaluation of carrier properties for dry powder inhalation applications
description Dry powder inhalation (DPI) formulations have been playing a critical part to increase the effectiveness of dry-powder delivery for inhalation. Most DPI formulations are composed of micron-size drug mixed with larger carrier particles, which are capable of diminishing aggregation, and aid in dispersion. Moreover, the performance of carrier-based DPI formulations is highly dependent upon interactions between the drug and the carrier particles. A combination of many factors such as particle size, shape, surface area, and morphology give an influence to the drug-carrier interaction forces and aerodynamic properties. In addition to those above factors, carrier surface properties play a key part in the dispersion and deposition of DPI formulations. This dissertation mainly focuses on investigating the effect of carrier surface characteristics in vitro deposition and drug-carrier particles interaction.
author2 Lau Wai Man
author_facet Lau Wai Man
Nguyen, Thi Quynh Ngoc
format Theses and Dissertations
author Nguyen, Thi Quynh Ngoc
author_sort Nguyen, Thi Quynh Ngoc
title Evaluation of carrier properties for dry powder inhalation applications
title_short Evaluation of carrier properties for dry powder inhalation applications
title_full Evaluation of carrier properties for dry powder inhalation applications
title_fullStr Evaluation of carrier properties for dry powder inhalation applications
title_full_unstemmed Evaluation of carrier properties for dry powder inhalation applications
title_sort evaluation of carrier properties for dry powder inhalation applications
publishDate 2017
url http://hdl.handle.net/10356/72365
_version_ 1759855686327468032