Dissolving microneedles for drug delivery

Microneedles are individual needles or arrays of needles in micro-scale widely used in transdermal drug delivery. They achieve painless administration with delivery of low but sufficient dose of therapeutic agents. Dissolving microneedles, made from biodegradable materials, are able to control drug...

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Main Author: Zhuang, Yinyin
Other Authors: Chen Peng
Format: Theses and Dissertations
Language:English
Published: 2017
Subjects:
Online Access:http://hdl.handle.net/10356/72372
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-723722023-03-03T16:01:00Z Dissolving microneedles for drug delivery Zhuang, Yinyin Chen Peng School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering Microneedles are individual needles or arrays of needles in micro-scale widely used in transdermal drug delivery. They achieve painless administration with delivery of low but sufficient dose of therapeutic agents. Dissolving microneedles, made from biodegradable materials, are able to control drug release by altering their compositions and fabrication processes. In this study, we designed a double-layered biodegradable microneedles model, which functioned as a two-speed drug delivery system with consistent release of two kinds of drugs in 2 hours and 2 days respectively in vitro. This model also possessed strong mechanical strength with elasticity in penetration of flat skin model and irregular surface model following delivery of inclusions capsulated in the microneedles, which provided skin diseases and ocular diseases with a beneficial drug delivery method in further study. ​Master of Science (Biomedical Engineering) 2017-06-16T03:45:10Z 2017-06-16T03:45:10Z 2017 Thesis http://hdl.handle.net/10356/72372 en 40 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Zhuang, Yinyin
Dissolving microneedles for drug delivery
description Microneedles are individual needles or arrays of needles in micro-scale widely used in transdermal drug delivery. They achieve painless administration with delivery of low but sufficient dose of therapeutic agents. Dissolving microneedles, made from biodegradable materials, are able to control drug release by altering their compositions and fabrication processes. In this study, we designed a double-layered biodegradable microneedles model, which functioned as a two-speed drug delivery system with consistent release of two kinds of drugs in 2 hours and 2 days respectively in vitro. This model also possessed strong mechanical strength with elasticity in penetration of flat skin model and irregular surface model following delivery of inclusions capsulated in the microneedles, which provided skin diseases and ocular diseases with a beneficial drug delivery method in further study.
author2 Chen Peng
author_facet Chen Peng
Zhuang, Yinyin
format Theses and Dissertations
author Zhuang, Yinyin
author_sort Zhuang, Yinyin
title Dissolving microneedles for drug delivery
title_short Dissolving microneedles for drug delivery
title_full Dissolving microneedles for drug delivery
title_fullStr Dissolving microneedles for drug delivery
title_full_unstemmed Dissolving microneedles for drug delivery
title_sort dissolving microneedles for drug delivery
publishDate 2017
url http://hdl.handle.net/10356/72372
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