Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector

The quantum mechanical studies of electronic transport properties of memantine-functionalized gold nanopore biosensor for natural and mutated DNA nucleobase detection are reported. In this study, gold electrode was functionalized with a modified diamondoid structure, called memantine, and the tunnel...

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Main Author: Kole Abhisek
Other Authors: K Radhakrishnan
Format: Theses and Dissertations
Language:English
Published: 2017
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Online Access:http://hdl.handle.net/10356/72580
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-725802023-07-04T16:05:20Z Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector Kole Abhisek K Radhakrishnan School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering The quantum mechanical studies of electronic transport properties of memantine-functionalized gold nanopore biosensor for natural and mutated DNA nucleobase detection are reported. In this study, gold electrode was functionalized with a modified diamondoid structure, called memantine, and the tunneling current arising from the nucleobases was investigated as it translates through the functionalized gold nanopore. Non-Equilibrium Green’s Function (NEGF) and density functional theorem (DFT) methods have been used to analyze and calculate the results. The transmission spectrum for each nucleobase is presented. In order to justify that the resonance peaks are originating from the nucleobases, the Projected Density of States (PDOS) of nucleobases were plotted and compared with their corresponding transmission spectrum. The electronic wave function related to the transmission and the device sensitivity has also been shown. The proposed device is demonstrated to detect various natural and mutated nucleobases with the sensitivity ranging from 103 to 107. Finally, we have investigated the differential conductance for various nucleobases. Master of Science (Electronics) 2017-08-29T06:12:56Z 2017-08-29T06:12:56Z 2017 Thesis http://hdl.handle.net/10356/72580 en 100 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Electrical and electronic engineering
spellingShingle DRNTU::Engineering::Electrical and electronic engineering
Kole Abhisek
Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector
description The quantum mechanical studies of electronic transport properties of memantine-functionalized gold nanopore biosensor for natural and mutated DNA nucleobase detection are reported. In this study, gold electrode was functionalized with a modified diamondoid structure, called memantine, and the tunneling current arising from the nucleobases was investigated as it translates through the functionalized gold nanopore. Non-Equilibrium Green’s Function (NEGF) and density functional theorem (DFT) methods have been used to analyze and calculate the results. The transmission spectrum for each nucleobase is presented. In order to justify that the resonance peaks are originating from the nucleobases, the Projected Density of States (PDOS) of nucleobases were plotted and compared with their corresponding transmission spectrum. The electronic wave function related to the transmission and the device sensitivity has also been shown. The proposed device is demonstrated to detect various natural and mutated nucleobases with the sensitivity ranging from 103 to 107. Finally, we have investigated the differential conductance for various nucleobases.
author2 K Radhakrishnan
author_facet K Radhakrishnan
Kole Abhisek
format Theses and Dissertations
author Kole Abhisek
author_sort Kole Abhisek
title Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector
title_short Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector
title_full Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector
title_fullStr Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector
title_full_unstemmed Quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore DNA nucleobase detector
title_sort quantum mechanical investigation of electronic transport properties of memantine-functionalized gold nanopore dna nucleobase detector
publishDate 2017
url http://hdl.handle.net/10356/72580
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