Revealing the adaptive evolution of pathogenic bacteria by next-generation sequencing

• Main Author: Ding, Yichen
• Other Authors: Yang Liang
• Format: Theses and Dissertations
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: http://hdl.handle.net/10356/73343
• Institution: Nanyang Technological University

Next-generation sequencing has been increasingly used to investigate the evolution of pathogenic bacteria, owing to its high throughput and accuracy. NGS can detect internal genetic mutations accumulated in the genomes of bacterial pathogens during their colonization in the hosts, whereas it can als...