Microfluidic chip with multiple functions for sensing

Microfluidics are widely used in many applications from cell sorting, cell lysis or even molecular detection purposes. In this study, polymethyl(methacrylate) (PMMA) is the material used for the fabrication of the microfluidic chip. The design of the microfluidic chip involves integrating the mixing...

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Main Author: Erh, Gavin Choon Hean
Other Authors: Chen Zhong
Format: Final Year Project
Language:English
Published: 2018
Subjects:
Online Access:http://hdl.handle.net/10356/73762
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-737622023-03-04T15:33:27Z Microfluidic chip with multiple functions for sensing Erh, Gavin Choon Hean Chen Zhong School of Materials Science and Engineering A*STAR Institute of Material Research and Engineering DRNTU::Engineering::Materials Microfluidics are widely used in many applications from cell sorting, cell lysis or even molecular detection purposes. In this study, polymethyl(methacrylate) (PMMA) is the material used for the fabrication of the microfluidic chip. The design of the microfluidic chip involves integrating the mixing of the gold nanoparticles with aqueous sodium chloride and the separation of the aggregated gold nanoparticles using microchannels. The design of the chip is replicated from the nickel mold onto the PMMA sample via thermal imprinting process followed by thermal embossing process to create a fully functioning chip. After multiple failed attempts in creating a successful sample, the final few samples were relatively acceptable. Fabricated microfluidic chip was tested for its mixing and size separation performance to prove the sample works. The developed system provides a new set of considerations to take note when using thermal processes in creating microfluidic chips for thermoplastic polymers. Bachelor of Engineering (Materials Engineering) 2018-04-09T01:09:54Z 2018-04-09T01:09:54Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/73762 en Nanyang Technological University 45 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials
spellingShingle DRNTU::Engineering::Materials
Erh, Gavin Choon Hean
Microfluidic chip with multiple functions for sensing
description Microfluidics are widely used in many applications from cell sorting, cell lysis or even molecular detection purposes. In this study, polymethyl(methacrylate) (PMMA) is the material used for the fabrication of the microfluidic chip. The design of the microfluidic chip involves integrating the mixing of the gold nanoparticles with aqueous sodium chloride and the separation of the aggregated gold nanoparticles using microchannels. The design of the chip is replicated from the nickel mold onto the PMMA sample via thermal imprinting process followed by thermal embossing process to create a fully functioning chip. After multiple failed attempts in creating a successful sample, the final few samples were relatively acceptable. Fabricated microfluidic chip was tested for its mixing and size separation performance to prove the sample works. The developed system provides a new set of considerations to take note when using thermal processes in creating microfluidic chips for thermoplastic polymers.
author2 Chen Zhong
author_facet Chen Zhong
Erh, Gavin Choon Hean
format Final Year Project
author Erh, Gavin Choon Hean
author_sort Erh, Gavin Choon Hean
title Microfluidic chip with multiple functions for sensing
title_short Microfluidic chip with multiple functions for sensing
title_full Microfluidic chip with multiple functions for sensing
title_fullStr Microfluidic chip with multiple functions for sensing
title_full_unstemmed Microfluidic chip with multiple functions for sensing
title_sort microfluidic chip with multiple functions for sensing
publishDate 2018
url http://hdl.handle.net/10356/73762
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