Validating the involvement of AGFG1 in X chromosome inactivation through CRISPR/Cas9 genome editing

• Main Author: Zheng, Zihao
• Other Authors: Zhang Li-Feng
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/74150
• Institution: Nanyang Technological University

X chromosome inactivation (XCI) is a phenomenon that occurs in mammals, whereby X chromosome is silenced in female to balance the X-linked gene dosage. Although XCI and the role of non-coding RNA Xist in XCI have been intensively studied, the exact mechanism and modulators of XCI are largely unclear...