Modeling MELAS-associated cardiac defects using patient-specific iPSC-derived cardiomyocytes and cardiac organoids

• Main Author: Phua, Qian Hua
• Other Authors: Soh Boon Seng
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/74163
• Institution: Nanyang Technological University

Mitochondrial diseases are a diverse family of maternally-inherited disorders that often result from mitochondrial DNA (mtDNA) mutations. These disorders are mostly heterogeneous and manifest as a broad spectrum of clinical phenotypes among patients. In this study, we will be utilising patient-speci...