Using human induced pluripotent stem cells to investigate the roles of astrocytes in spinal muscular atrophy

• Main Author: Loh, Sharon Jia Hui
• Other Authors: Albert I. Chen
• Format: Theses and Dissertations
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/74828
• Institution: Nanyang Technological University

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by the mutation of SMN1 gene and which is characterized by the selective degeneration of lower motor neurons. Through the years, it has become more evident that SMA is not solely a disease of the lower motor neurons, but other cell type...