Waterproof bioelectrodes for electrophysiological interfacing applications

The inadequate adhesion of underwater wearable devices on the skin is a major drawback for biomedical and healthcare industries. As a result, development of styrene-ethylene-butylene-styrene/polydopamine (SEBS/PDA) coated silk protein hydrogel film was initiated to synthesize waterproof and adhesive...

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Main Author: Ng, You Shan
Other Authors: Chen Xiaodong
Format: Final Year Project
Language:English
Published: 2018
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Online Access:http://hdl.handle.net/10356/74985
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-749852023-03-04T15:36:47Z Waterproof bioelectrodes for electrophysiological interfacing applications Ng, You Shan Chen Xiaodong School of Materials Science and Engineering DRNTU::Engineering The inadequate adhesion of underwater wearable devices on the skin is a major drawback for biomedical and healthcare industries. As a result, development of styrene-ethylene-butylene-styrene/polydopamine (SEBS/PDA) coated silk protein hydrogel film was initiated to synthesize waterproof and adhesive patchable devices for long term biomedical usage. In this study, the synthesis of SEBS/PDA coated silk protein hydrogel film had been achieved. Silk fibroin was first extracted by washing silk strands, followed by gelation of silk fibroin solution to obtain a silk protein hydrogel film. Subsequently, pH 8.5 dopamine solution was poured onto the silk protein hydrogel film and allowed to undergo oxidative polymerization to form a PDA coated silk protein hydrogel film (PDA/silk film). Thereafter, SEBS film was synthesized through an evaporation process and gold nanoparticles (AuNPs) were deposited onto the SEBS film by thermal evaporation, to form a SEBS/Au film. Lastly, the SEBS/Au film was adhered onto the PDA/silk film to form a SEBS/PDA coated silk protein hydrogel composite material. The effectiveness of the adhesive strength of the composite material in wet conditions was assessed based on whether the composite material can remain adhered onto the skin in water. With reference to the experimental results, SEBS/PDA coated silk protein hydrogel film was observed to have remained adhered onto the skin when fully submerged in water. Furthermore, the film was observed to be flexible as vigorous movements of the arm did not result in the film peeling off from the skin or surface cracks in the film. It also remained tightly adhered to the skin even when the arm was taken out of the water, this showed that the adhesive property was retained despite being exposed to a wet environment. This result demonstrated that the incorporation of silk fibres, bioinspired dopamine-based wet adhesives, AuNPs and SEBS to form a composite material, has a huge potential for the fabrication of waterproof and highly adhesive patches for electrophysiological applications. However, the results did not consider the effectiveness of the adhesion strength of the film to remain adhered onto the skin in various pH environments. Thus, future researches can aid to enhance the use of SEBS/PDA coated silk protein hydrogel film in varying pH environments, allowing the material to retain its adhesive properties in different pH environments and ensuring accurate and reliable medical diagnoses for long term usage. Bachelor of Engineering (Materials Engineering) 2018-05-25T07:42:32Z 2018-05-25T07:42:32Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/74985 en Nanyang Technological University 46 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering
spellingShingle DRNTU::Engineering
Ng, You Shan
Waterproof bioelectrodes for electrophysiological interfacing applications
description The inadequate adhesion of underwater wearable devices on the skin is a major drawback for biomedical and healthcare industries. As a result, development of styrene-ethylene-butylene-styrene/polydopamine (SEBS/PDA) coated silk protein hydrogel film was initiated to synthesize waterproof and adhesive patchable devices for long term biomedical usage. In this study, the synthesis of SEBS/PDA coated silk protein hydrogel film had been achieved. Silk fibroin was first extracted by washing silk strands, followed by gelation of silk fibroin solution to obtain a silk protein hydrogel film. Subsequently, pH 8.5 dopamine solution was poured onto the silk protein hydrogel film and allowed to undergo oxidative polymerization to form a PDA coated silk protein hydrogel film (PDA/silk film). Thereafter, SEBS film was synthesized through an evaporation process and gold nanoparticles (AuNPs) were deposited onto the SEBS film by thermal evaporation, to form a SEBS/Au film. Lastly, the SEBS/Au film was adhered onto the PDA/silk film to form a SEBS/PDA coated silk protein hydrogel composite material. The effectiveness of the adhesive strength of the composite material in wet conditions was assessed based on whether the composite material can remain adhered onto the skin in water. With reference to the experimental results, SEBS/PDA coated silk protein hydrogel film was observed to have remained adhered onto the skin when fully submerged in water. Furthermore, the film was observed to be flexible as vigorous movements of the arm did not result in the film peeling off from the skin or surface cracks in the film. It also remained tightly adhered to the skin even when the arm was taken out of the water, this showed that the adhesive property was retained despite being exposed to a wet environment. This result demonstrated that the incorporation of silk fibres, bioinspired dopamine-based wet adhesives, AuNPs and SEBS to form a composite material, has a huge potential for the fabrication of waterproof and highly adhesive patches for electrophysiological applications. However, the results did not consider the effectiveness of the adhesion strength of the film to remain adhered onto the skin in various pH environments. Thus, future researches can aid to enhance the use of SEBS/PDA coated silk protein hydrogel film in varying pH environments, allowing the material to retain its adhesive properties in different pH environments and ensuring accurate and reliable medical diagnoses for long term usage.
author2 Chen Xiaodong
author_facet Chen Xiaodong
Ng, You Shan
format Final Year Project
author Ng, You Shan
author_sort Ng, You Shan
title Waterproof bioelectrodes for electrophysiological interfacing applications
title_short Waterproof bioelectrodes for electrophysiological interfacing applications
title_full Waterproof bioelectrodes for electrophysiological interfacing applications
title_fullStr Waterproof bioelectrodes for electrophysiological interfacing applications
title_full_unstemmed Waterproof bioelectrodes for electrophysiological interfacing applications
title_sort waterproof bioelectrodes for electrophysiological interfacing applications
publishDate 2018
url http://hdl.handle.net/10356/74985
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