Development of self-adhesive mussel-inspired swellable microneedle for transdermal application
Inspired by the adhesive protein secreated by the Mussel which contains the dopamine catechoamine that gives it waterproofing adhesion ability. Dopa has been found in the adhesive proteins of mussels which allow it to resist dislodging from incoming wave. The reason for this strong and water-r...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/75174 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Inspired by the adhesive protein secreated by the Mussel which contains the dopamine
catechoamine that gives it waterproofing adhesion ability. Dopa has been found in the adhesive
proteins of mussels which allow it to resist dislodging from incoming wave. The reason for this
strong and water-resistant adhesion of the mussels to the solid surfaces in the sea is the cateholic
functionality of Dopa which have been functionalized with various polymers to provide
adhesive, sealant, coating and anchoring properties in biomedical applications particularly.
Additionally, Dopamines have half-life of a few minutes when circulating in the blood where
they can be degraded by methylation by catechol-O-methyltransferases (COMT). In this study,
dopamine was used to functionalize methacrylated hydroluronic acid (MeHA) to product a
biocompatible and biodegradable macromer. We have successfully synthesized a
biocompatible and degradable adhesive based on hyaluronic acid derivative (catechol
methacrylate modified hyaluronic acid) and demonstrated its adhesive property; able to hold at
least 02 N/cm2 while maintaining its structural integrity. The initial objective of this study is to
develop a self-adhesive microneedle. However due to the time spend on synthesizing the CA
MeHA polymer and the difficulties faced in the fabrication of the microneedle, the optimization
and fabrication of the CA-MeHA microneedle will be left for future works. CA-MeHA is
biodegradable, biocompatible and non-immunogenic hence it will not invoke any
inflammatory response or irritation. With extensive research, the development of CA-MeHA
adhesives could potentially open up various applications in the medical and therapeutic field. |
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