Structural and biochemical study of kindlin-3 in integrin activation

• المؤلف الرئيسي: Bu, Wenting
• مؤلفون آخرون: Gao Yonggui
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/75441
• المؤسسة: Nanyang Technological University

Kindlin-3, a member of the FERM family proteins, functions as an adaptor between cell membrane and cytoskeleton proteins. It is mostly expressed in hematopoietic and endothelial cells. Leukocyte adhesion deficiency syndrome (LAD-III) in human has been linked to the expression of mutant Kindlin-3 pro...