Biodegradable semiconducting polymer nanoparticles (spns) in theranostic application

• Main Author: Nur Hafizah Zulkifli
• Other Authors: Pu Kanyi
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/75487
• Institution: Nanyang Technological University

This final year report describes the overview of the different experiments that were conducted in making semiconducting polymer nanoparticles (SPNs). The SPNs were then tested in theranostic applications. The in vitro characterization testing will include the measurement of absorption, the dynamic light scattering (DLS) for nanoparticle size, transmission electron microscopy (TEM) and fluorescence testing. With the use of fluorescence testing, presence of singlet oxygen was also tested and there was no singlet oxygen present at the end of the testing. The SPNs were also examined to see if they were biodegradable and whether SPNs were able to enter a type of macrophage cells. The experiments showed that SPNs are biodegradable and were able to enter macrophage RAW264.7 cells. A future prospect would include the ability to effectively degrade the SPNs in cells for future clinical use.