Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties

In modern hospitals, catheters have become indispensable as such Catheter-associated urinary tract infections (CAUTIs) have become the most prevalent nosocomial infections. The leading cause of CAUTIs is the formation of biofilm by bacteria in catheters which are difficult to treat once they are for...

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Main Author: Tan, Jethro Jing Hao
Other Authors: Chan Bee Eng, Mary
Format: Final Year Project
Language:English
Published: 2018
Subjects:
Online Access:http://hdl.handle.net/10356/75576
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-755762023-03-03T15:39:58Z Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties Tan, Jethro Jing Hao Chan Bee Eng, Mary School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering DRNTU::Science::Biological sciences::Biochemistry DRNTU::Science::Biological sciences::Microbiology In modern hospitals, catheters have become indispensable as such Catheter-associated urinary tract infections (CAUTIs) have become the most prevalent nosocomial infections. The leading cause of CAUTIs is the formation of biofilm by bacteria in catheters which are difficult to treat once they are formed due to a strong resistance to antibiotics and the host immune system. In this study the aim is to prevent biofilm formation by coating a surface to express both antibacterial and antifouling properties. Polydimethylsiloxane (PDMS) is extensively used to make urinary catheters and will be base surface to be modified. The initial layer that was deposited onto the PDMS surface is polydopamine (PDA) due to its versatility of having an amine and catechol group. Polyaminopropyl biguanide (PHMB) and polyvinylpyrrolidone (PVP) are bound onto the PDA layer to the express antibacterial and antifouling properties respectively. Lastly, Staphylococcus aureus was used to test the efficacy of the coating. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2018-06-04T06:47:49Z 2018-06-04T06:47:49Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/75576 en Nanyang Technological University 39 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
DRNTU::Science::Biological sciences::Biochemistry
DRNTU::Science::Biological sciences::Microbiology
spellingShingle DRNTU::Engineering::Bioengineering
DRNTU::Science::Biological sciences::Biochemistry
DRNTU::Science::Biological sciences::Microbiology
Tan, Jethro Jing Hao
Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties
description In modern hospitals, catheters have become indispensable as such Catheter-associated urinary tract infections (CAUTIs) have become the most prevalent nosocomial infections. The leading cause of CAUTIs is the formation of biofilm by bacteria in catheters which are difficult to treat once they are formed due to a strong resistance to antibiotics and the host immune system. In this study the aim is to prevent biofilm formation by coating a surface to express both antibacterial and antifouling properties. Polydimethylsiloxane (PDMS) is extensively used to make urinary catheters and will be base surface to be modified. The initial layer that was deposited onto the PDMS surface is polydopamine (PDA) due to its versatility of having an amine and catechol group. Polyaminopropyl biguanide (PHMB) and polyvinylpyrrolidone (PVP) are bound onto the PDA layer to the express antibacterial and antifouling properties respectively. Lastly, Staphylococcus aureus was used to test the efficacy of the coating.
author2 Chan Bee Eng, Mary
author_facet Chan Bee Eng, Mary
Tan, Jethro Jing Hao
format Final Year Project
author Tan, Jethro Jing Hao
author_sort Tan, Jethro Jing Hao
title Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties
title_short Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties
title_full Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties
title_fullStr Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties
title_full_unstemmed Develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties
title_sort develop an antibiofilm coating for polydimethylsiloxane (pdms) catheters by incorporating both antibacterial and antifouling properties
publishDate 2018
url http://hdl.handle.net/10356/75576
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