Developing ultrasound-responsive and drug delivery nanoparticles for acoustic implantation

• Main Author: Chen, Jia Yi
• Other Authors: James Jing Kwan
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/75592
• Institution: Nanyang Technological University

Atherosclerotic lesions that leads to stroke and acute myocardial infarction remains an issue without a perfect cure. This project focuses on targeted therapy for atherosclerosis, which is achieved using ultrasound-induced cavitation to transport and embed therapeutic drug-loaded agents directly at the site of the lesion Gold nanocone were fabricated and physically and acoustically analyzed. These Gold nanocones had an average diameter of 105.6nm. It was evident that forming nanocones was sensitive to the protocol. In order to nucleate cavitation, Gold nanocones must trap a nanobubble. Thus, Gold nanocones were first pegylated before freeze drying. The PEG prevents agglomeration when suspended for a gas nanobubble to be trapped in the crevice. From the resuspended nanocones, ultrasound was applied to determine if there are any cavitation activities.