Design of novel F-ATP synthase inhibitors of mycobacterium tuberculosis

• المؤلف الرئيسي: Hotra, Adam
• مؤلفون آخرون: Gerhard Gruber
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/75829
• المؤسسة: Nanyang Technological University

F1FO ATP synthase of Mycobacterium tuberculosis is an attractive and intensively-studied drug target. Adenosine triphosphate (ATP) is necessary for cell growth and is vital for cell survival, especially in the case of dormant Mycobacterium. In 2012, an inhibitor of F1FO ATP synthase, Bedaquiline (BD...